Effect of Reduning injection combined with azithromycin in the treatment of Mycoplasma pneumonia in children and its influence on the levels of inflammatory factors
Objective To explore the clinical effect of Reduning injection combined with azithromycin in the treatment of Mycoplasma pneumonia in children.Methods 48 children with Mycoplasma pneumonia were selected as the research subjects,and they were randomly divided into a control group and an observation group,with 24 cases in each group.The control group was treated with conventional azithromycin,while the observation group was combined with Reduning injection on this basis.The clinical efficacy,symptom improvement time,T-lymphocyte subsets and serum inflammatory factors before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 100.00%,which was significantly higher than 79.17%of the control group(P<0.05).In the observation group,the fever resolution time was(2.42±0.55)d,the cough disappearance time was(6.41±1.31)d and the lung rale disappearance time was(4.54±1.07)d,which were significantly shorter than(3.67±1.01),(8.57±2.58)and(6.61±1.43)d in the control group(P<0.05).After treatment,CD3+,CD4+,CD8+,CD4+/CD8+in the observation group were(51.78±6.10)%,(47.14±5.52)%,(22.90±4.53)%,(2.46±0.84);in the control group,CD3+,CD4+,CD8+,CD4+/CD8+were(46.16±7.27)%,(42.93±7.81)%,(25.23±1.69)%,(1.41±0.58).After treatment,the observation group had lower CD8+than that in the control group;CD3+,CD4+and CD4+/CD8+in the observation group were higher than those in the control group(P<0.05).After treatment,the tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)in both groups were improved;TNF-α,IL-6 and CRP in the observation group were(46.09±3.47)ng/L,(6.05±1.27)pg/ml and(4.05±1.09)mg/L,which were significantly better than(59.77±4.55)ng/L,(7.47±1.94)pg/ml and(5.39±1.25)mg/L in the control group(P<0.05).Conclusion The use of azithromycin combined with Reduning injection in the treatment of Mycoplasma pneumonia in children has a higher effective rate and can promote the recovery of children,which can be vigorously promoted in clinical practice.
Mycoplasma pneumonia in childrenAzithromycinReduningLung functionStress indicators
万方数据
维普
