Analysis of the efficacy of ursodeoxycholic acid capsules combined with ademetionine intravenous infusion on patients with intrahepatic cholestasis of pregnancy
Objective To explore the efficacy of ursodeoxycholic acid capsules combined with ademetionine intravenous infusion on patients with intrahepatic cholestasis of pregnancy.Methods 105 patients with intrahepatic cholestasis of pregnancy were grouped into a control group(52 cases)and an observation group(53 cases)according to random number table method.Patients in the control group were treated with ursodeoxycholic acid capsules orally,and patients in the observation group were treated with ursodeoxycholic acid capsules orally and adenosine methionine intravenously.The therapeutic effect,liver function index[alanine aminotrasferase(ALT),aspartate transaminase(AST),alkaline phosphatase(ALP),direct bilirubin(DBIL),total bilirubin(TBIL),total bile acid(TBA)]and adverse pregnancy outcome were compared between the two groups.Results The total effective rate of the observation group was 98.11%,which was higher than 76.92%of the control group(P<0.05).After 2 weeks of treatment,ALT,AST,ALP,DBIL,TBIL and TBA in the observation group were(82.34±10.56)U/L,(103.12±10.16)U/L,(51.23±8.54)U/L,(6.14±1.43)μmol/L,(18.23±3.24)μmol/L and(18.79±3.65)μmol/L,which were lower than(128.56±13.27)U/L,(156.43±13.19)U/L,(89.96±9.67)U/L,(9.68±1.62)μmol/L,(24.05±3.78)μmol/L and(29.94±4.37)μmol/L in the control group(P<0.05).After 2 weeks of treatment,ALT,AST,ALP,DBIL,TBIL and TBA in both groups were lower than those before treatment(P<0.05).The incidence of adverse pregnancy outcome in the observation group was 5.66%,which was lower than 23.08%in the control group(P<0.05).Conclusion Ursodeoxycholic acid capsules combined with ademetionine intravenous infusion for the treatment of intrahepatic cholestasis of pregnancy can improve the therapeutic effect,liver function indexes and maternal and infant pregnancy outcomes,and is worthy of clinical promotion.
Intrahepatic cholestasis of pregnancyUrsodeoxycholic acid capsulesAdemetionineTherapeutic effectLiver function indexAdverse pregnancy outcome
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