Effect of maintenance hemodialysis combined with cinacalcet on patients with end-stage renal disease
Objective To study and analyze the effect of maintenance hemodialysis combined with cinacalcet on patients with end-stage renal disease.Methods 76 patients with end-stage renal disease were divided into two groups,i.e.,the control group and the study group,each with 38 cases.The control group was treated with maintenance hemodialysis,and the study group was treated with cinacalcet on the basis of the control group.The serum phosphorus and calcium concentration,parathyroid function,renal function,inflammatory markers,blood routine and blood biochemistry were compared between the two groups.Results After treatment,the serum phosphorus concentration was significantly lower and the serum calcium concentration was significantly higher than those before treatment in both groups,and there was statistical significance(P<0.05).There was no significant difference in serum calcium concentration between the two groups after treatment(P>0.05).The serum phosphorus concentration in the study group was(1.70±0.13)mmol/L after treatment,which was lower than(1.96±0.20)mmol/L in the control group,and there was statistical significance(P<0.05).After treatment,the intact parathyroid hormone and alkaline phosphatase in the study group were(138.95±22.66)ng/L and(81.30±6.38)U/L,which were lower than(329.63±47.35)ng/L and(101.25±14.95)U/L in the control group,and there was statistical significance(t=22.392,7.566;P=0.000,0.000<0.05).After treatment,the serum creatinine of the study group was(523.63±9.14)μmol/L and blood urea nitrogen was(18.82±1.81)mmol/L,which were lower than(639.63±11.24)μmol/L and(19.95±2.58)mmol/L of the control group,and there was statistical significance(t=49.359,2.210;P=0.000,0.030<0.05).After treatment,the levels of procalcitonin and hypersensitive C-reactive protein in the study group were(0.59±0.03)ng/ml and(5.35±1.29)mg/L,both were lower than(0.65±0.03)ng/ml and(7.55±1.50)mg/L in the control group,and there was statistical significance(t=8.718,6.855;P=0.000,0.000<0.05).After treatment,the albumin of the study group was(34.52±0.41)g/L,the globulin was(23.14±0.31)g/L,and the white blood cell count was(5.11±0.21)×109/L,which were higher than(32.11±0.31)g/L,(21.33±0.30)g/L,and(4.62±0.22)×109/L of the control group,and there was statistical significance(t=28.903,25.864,9.932;P=0.000,0.000,0.000<0.05).Conclusion The combined application of maintenance hemodialysis and cinacalcet in patients with end-stage renal disease has a remarkable effect,which can stable the blood phosphorus level and promote the improvement of renal function,and is worthy of promotion and utilization.
Maintenance hemodialysisCinacalcetEnd-stage renal diseaseRenal function
万方数据
维普
