Comparison of clinical effects of nicorandil combined with clopidogrel or ticagrelor in patients undergoing PCI
Objective To explore the clinical effect of nicorandil combined with clopidogrel or ticagrelor in patients undergoing percutaneous coronary intervention(PCI).Methods 100 patients undergoing PCI were randomly selected and divided into clopidogrel group and ticagrelor group using a lot drawing method,with 50 patients in each group.Both groups of patients were treated with nicorandil,and on this basis,the clopidogrel group was treated with clopidogrel,and the ticagrelor group was treated with ticagrelor.Patients in both groups were compared in terms of cardiac function indicators[left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),and left ventricular ejection fraction(LVEF)],incidence of cardiovascular adverse events,and TIMI blood flow grading and inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and C-reactive protein(CRP)]levels.Results 1 week after surgery,LVEDD,LVESD and LVEF were improved in both groups;ticagrelor group had LVEDD of(46.14±4.05)mm and LVESD of(30.01±3.07)mm,which were lower than(52.03±3.37)and(35.66±3.25)mm in clopidogrel group;LVEF was(59.38±4.37)%in ticagrelor group,which was higher than(50.75±4.06)%in clopidogrel group;there was statistical difference between the two groups(P<0.05).The incidence of cardiovascular adverse events in ticagrelor group was 4.00%,which was lower than 16.00%in clopidogrel group,and there was statistical difference between the two groups(P<0.05).1 week after surgery,the levels of TNF-α,CRP and IL-6 in ticagrelor group were(3.32±0.66)ng/ml,(3.44±0.87)mg/L and(2.04±0.66)ng/L,which were significantly lower than(4.01±0.81)ng/ml,(4.22±1.63)mg/L and(3.05±0.83)ng/L in clopidogrel group,and there was statistical difference between the two groups(P<0.05).The blood flow grading of ticagrelor group was significantly better than that of clopidogrel group,and there was statistical difference between the two groups(Z=3.313,P=0.001<0.05).Conclusion On the basis of nicorandil,the use of ticagrelor or clopidogrel has significant effects,which can improve cardiac function and prevent the development of cardiovascular adverse events in patients undergoing PCI surgery.However,ticagrelor has a better effect on improveing cardiac function indicators,reducing inflammatory reactions,and is safer to use,which is more conducive to improving patient prognosis.
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