Objective To analyze the effect of Huangkui capsule and dapagliflozin in the treatment of diabetes nephropathy.Methods 60 patients with diabetes nephropathy were divided into three groups by lottery method,with 30 patients in each group.The control group was treated with dapagliflozin,and the treatment group was treated with Huangkui capsule and dapagliflozin.Both groups were compared in terms of clinical efficacy and blood glucose indexes(fasting blood glucose,2 h postprandial blood glucose,glycated hemoglobin),lipid indexes[triglycerides(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)],renal function indexes[cystatin C(Cys-C),glomerular filtration rate(GFR),urinary albumin excretion rate(UAER),serum creatinine(Cr),blood urea nitrogen(BUN)],inflammation factors[hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)],and occurrence of adverse reactions.Results The total clinical effective rate of the treatment group was 96.67%,which was higher than 73.33%of the control group(P<0.05).After treatment,the fasting blood glucose of the treatment group was(5.03±1.25)mmol/L,the 2 h postprandial blood glucose was(7.75±0.64)mmol/L and the glycated hemoglobin was(4.81±1.30)%,which were significantly lower than(6.65±1.52)mmol/L,(8.10±0.51)mmol/L and(6.27±1.52)%of the control group(P<0.05).After treatment,TG,TC and LDL-C levels in the treatment group were(1.10±0.14),(3.38±0.75)and(1.92±0.55)mmol/L,which were significantly lower than(1.26±0.20),(4.12±0.55)and(2.29±0.62)mmol/L in the control group(P<0.05).After treatment,the levels of Cys-C,GFR,UAER,Cr and BUN in the treatment group were(1.19±0.44)mg/L,(84.15±9.26)ml/min,(445.30±75.12)μg/min,(80.35±10.15)μmol/L and(7.21±1.05)mmol/L,which were significantly lower than(1.69±0.48)mg/L,(89.10±8.30)ml/min,(623.58±101.63)μg/min,(86.45±10.03)μmol/L and(8.08±0.96)mmol/L in the control group(P<0.05).After treatment,the levels of hs-CRP and IL-6 in the treatment group were(5.12±0.65)mg/L and(203.42±25.15)pg/ml,which were significantly lower than(6.90±0.70)mg/L and(258.90±24.46)pg/ml in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Huangkui capsule and dapagliflozin are effective in treating diabetes nephropathy patients,which can improve the blood glucose indexes,blood lipid indexes,renal function indexes,and inflammatory factors while guaranteeing the effectiveness and safety,and is worth to be popularized.
NETL
NSTL
万方数据
