The application of dynamic monitoring of infection indicators at 12-h intervals after birth in the diagnosis of early-onset neonatal sepsis
Objective To explore the value of dynamic monitoring of infection indicators at 12-h intervals after birth in the diagnosis of early-onset neonatal sepsis(EONS).Methods Clinical data of 120 neonates were retrospectively analyzed,including 60 EONS neonates EONS without serious complications as the EONS group and 60 neonates without infection as the control group.The indicators of infection[white blood cells(WBC),neutrophil percentage(NEU%),platelets(PLT),C-reactive protein(CRP),and procalcitonin(PCT)]were tested at admission and 12-h post-admission in both groups of neonates.Differences in each index at the same time point between the two groups of neonates and changes in each index at different time points in each of the two groups were compared.Results At admission,WBC,NEU%,PLT,CRP and PCT of the EONS group were(12.5±3.2)×109/L,(60.2±7.5)%,(250±50)×109/L,(5.3±2.8)mg/L and(1.2±0.5)μg/L,and those of the control group were(11.8±2.9)×109/L,(59.5±8.1)%,(248±48)×109/L,(4.7±2.6)mg/L and(1.1±0.4)μg/L.The difference was not statistically significant in comparison(P>0.05).At 12-h post-admission,WBC,NEU%,PLT,CRP,and PCT of the EONS group were(18.5±4.3)×109/L,(75.8±8.6)%,(150±35)×109/L,(65.3±15.6)mg/L,and(10.8±3.2)μg/L,and those of the control group were(12.1±3.1)×109/L,(61.2±9.0)%,(240±55)×109/L,(5.8±3.2)mg/L,and(1.0±0.3)μg/L.The difference was statistically significant in comparison(P<0.05).In the EONS group,WBC,NEU%,PLT,CRP and PCT at 12-h post-admission were significantly different from those at admission(P<0.05).In the control group,there was no significant difference in WBC,NEU%,PLT,CRP and PCT at admission and 12-h post-admission(P>0.05).Conclusion Dynamic monitoring of infection indication at 12-h intervals after birth can improve the diagnostic accuracy of EONS,aiding in earlier and more precise diagnosis of EONS.
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