Comparison on application value of oral or subcutaneous morphine for analgesia in analgesic treatment of advanced cancer pain patients
Objective To compare the application effect of oral or subcutaneous morphine for analgesia in analgesic treatment of advanced cancer pain patients.Methods A retrospective study was conducted on 70 patients with advanced cancer pain,and they were divided into an oral group(35 cases)and an injection group(35 cases)according to different treatment methods.The control group was given oxycodone hydrochloride sustained-release tablets combined with morphine hydrochloride sustained-release tablets,and the injection group was given oxycodone hydrochloride sustained-release tablets combined with morphine hydrochloride injection.The pain level,pain relief,clinical analgesia indexes,and occurrence of adverse reactions were compared between the two groups.Results There was no significant difference in numerical rating scale(NRS)scores between the two groups before treatment and 1 d after treatment(P>0.05).3 and 7 d after treatment,the NRS scores in the injection group were(3.06±0.18)and(1.93±0.23)points,which were lower than(3.28±0.24)and(2.63±0.19)points in the oral group,and there was statistical significance(P<0.05).After treatment,the total effective rate of the injection group(94.29%)was higher than that of the oral group(88.57%),but there was no statistical significance(P>0.05).After treatment,the β-endorphin(β-EP)levels in both groups were increased,and the prostaglandin E2(PGE2)and 5-hydroxytryptamine(5-HT)levels were decreased,and there was statistical significance(P<0.05).After treatment,β-EP in the injection group was(188.16±6.32)ng/L,which was higher than(162.31±6.47)ng/L in the oral group;the PGE2 in the injection group was(36.59±5.62)ng/L and 5-HT was(122.65±7.23)ng/L,which were lower than(42.67±6.43)and(149.46±7.68)ng/L in the oral group;there was statistical significance(P<0.05).There was no statistical significance in the total incidence of adverse reactions between the injection group(22.86%)and the oral group(17.14%)(P>0.05).Conclusion The clinical effect of subcutaneous injection of oxycodone hydrochloride sustained-release tablets combined with morphine is more significant than that of oral morphine,which can further relieve patients'pain and reduce clinical pain indicators with high safety.
Advanced cancer painOxycodone hydrochlorideMorphinePain levelOral administrationSubcutaneous injection
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