Study on correlation of 24-h urinary sodium and 24-h urinary microalbumin with left ventricular mass index in elderly patients with essential hypertension
Objective To explore the correlation of 24-h urinary sodium and 24-h urinary microalbumin with left ventricular mass index(LVMI)in elderly patients with essential hypertension.Methods 126 elderly patients with essential hypertension were selected,and the patients were divided into an observation group(with elevated 24-h urinary microalbumin,≥30 mg/24 h,61 cases)and a control group(with normal 24-h urinary microalbumin,<30 mg/24 h,65 cases)according to the 24-h urinary microalbumin.Patients in both groups received blood pressure measurement,urine biochemistry test,blood biochemistry test,and left ventricular mass index measurement.Blood pressure,urine biochemistry,blood biochemistry,and left ventricular mass index were compared in both groups,and correlation analysis was performed.Results There was no statistically significant difference in terms of heart rate,total cholesterol,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),fasting blood glucose,blood sodium,blood potassium,systolic blood pressure(SBP),diastolic blood pressure(DBP)and creatinine between the observation group and the control group(P>0.05).The 24-h urinary microalbumin of the observation group was(46.6±4.5)mg/24 h,the 24-h urinary sodium was(333.4±5.1)mmol/24 h and the left ventricular mass index was(142.5±2.1)g/m2,which were significantly higher than(18.1±3.2)mg/24 h,(176.3±3.6)mmol/24 h and(96.5±4.2)g/m2 in the control group(P<0.05).In the control group,24-h urinary sodium was positively correlated with SBP,left ventricular mass index,and age(r=0.236,0.178,0.104;P<0.05),and there was no significant correlation with heart rate,total cholesterol,LDL-C,HDL-C,blood sodium,blood potassium,creatinine,fasting blood glucose,and DBP(P>0.05).In the observation group,24-h urinary sodium was positively correlated with 24-h urinary microalbumin,creatinine,SBP,left ventricular mass index,DBP,and age(r=0.106,0.038,0.148,0.112,0.134,0.201;P<0.05),and there was no significant correlation with heart rate,total cholesterol,LDL-C,HDL-C,blood sodium,blood potassium,and fasting blood glucose(P>0.05).Conclusion In elderly patients with essential hypertension,24-h urinary sodium is positively correlated with 24-h urinary microalbumin and left ventricular mass index,and 24-h urinary sodium reflects early changes in left ventricular mass index.
Essential hypertensionUrinary microalbuminUrinary sodiumLeft ventricular mass index
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