摘要
目的 浅析老年呼吸衰竭采取抗感染药物联合双水平气道正压通气呼吸机(BiPAP)无创通气治疗的临床价值.方法 68 例老年呼吸衰竭患者,依据随机数字表法分为对照组与研究组,各 34 例,对照组接受常规抗感染药物,研究组接受抗感染药物联合BiPAP无创通气治疗.比较两组患者治疗前后的心率、呼吸频率、动脉血气指标[动脉血二氧化碳分压(PaCO2)、动脉血氧分压(PaO2)、动脉血氧饱和度(SaO2)]、肺功能指标[第 1 秒钟用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC]、不良反应发生情况.结果 治疗 1、2 d后,研究组患者心率分别为(97.42±7.62)、(85.13±4.91)次/min,呼吸频率分别为(21.72±6.50)、(20.05±4.13)次/min,均低于对照组的(101.58±9.34)、(99.72±7.68)、(26.97±5.87)、(24.97±4.25)次/min,差异有统计学意义(P<0.05).治疗 7 d后,研究组患者PaCO2(44.08±2.67)mm Hg(1 mm Hg=0.133 kPa)低于对照组的(50.27±3.16)mm Hg,PaO2(79.14±5.91)mm Hg、SaO2(91.98±8.67)%均高于对照组的(67.15±5.12)mm Hg、(83.41±8.52)%,差异有统计学意义(P<0.05).治疗 7 d,研究组患者FEV1(2.04±0.72)L、FVC(3.11±0.41)L、FEV1/FVC(72.47±9.27)%均高于对照组的(1.68±0.61)L、(2.67±0.48)L、(64.18±8.26)%,差异有统计学意义(P<0.05).研究组不良反应发生率 8.82%低于对照组的 29.41%,差异有统计学意义(P<0.05).结论 老年呼吸衰竭患者给予抗感染药物联合BiPAP无创通气治疗具有积极意义,可有效改善患者的临床症状,提高氧合及肺功能,具有推广价值.
Abstract
Objective To analyze the clinical value of anti-infective drugs combined with bi-level positive airway pressure(BiPAP)non-invasive ventilation in elderly patients with respiratory failure.Methods 68 elderly patients with respiratory failure were selected.According to random number table,patients were assigned to a control group and a study group,each with 34 cases.The control group received conventional anti-infective drugs,and the study group received anti-infective drugs combined with BiPAP non-invasive ventilation.Patients in both groups were compared in terms of heart rate,respiratory rate,arterial blood gas indexes[arterial partial pressure of carbon dioxide(PaCO2),arterial partial pressure of oxygen(PaO2),and blood oxygen saturation(SaO2)],pulmonary function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC]before and after treatment,and the occurrence of adverse reactions.Results After 1 and 2 d of treatment,the heart rate in the study group were(97.42±7.62)and(85.13±4.91)beats/min,and the respiratory rate were(21.72±6.50)and(20.05±4.13)times/min,which were lower than(101.58±9.34),(99.72±7.68)beats/min and(26.97±5.87),(24.97±4.25)times/min in the control group.The difference was statistically significant(P<0.05).After 7 d of treatment,PaCO2 was(44.08±2.67)mm Hg(1 mm Hg=0.133 kPa)in the study group,which was lower than(50.27±3.16)mm Hg in the control group;the study group had PaO2 of(79.14±5.91)mm Hg and SaO2 of(91.98±8.67)%,which were higher than(67.15±5.12)mm Hg and(83.41±8.52)%in the control group;the difference was statistically significant(P<0.05).After 7 d of treatment,the study group had FEV1 of(2.04±0.72)L,FVC of(3.11±0.41)L,FEV1/FVC of(72.47±9.27)%,which were higher than(1.68±0.61)L,(2.67±0.48)L,(64.18±8.26)%in the control group.The difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was 8.82%,which was lower than 29.41%in the control group,and the difference was statistically significant(P<0.05).Conclusion The anti-infective drugs combined with BiPAP non-invasive ventilation has positive significance in elderly patients with respiratory failure,which can effectively improve the clinical symptoms of patients,improve the oxygenation indexes and pulmonary function,and has popularization value.
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