Efficacy observation of anti-infective drugs combined with BiPAP non-invasive ventilation in elderly patients with respiratory failure
Objective To analyze the clinical value of anti-infective drugs combined with bi-level positive airway pressure(BiPAP)non-invasive ventilation in elderly patients with respiratory failure.Methods 68 elderly patients with respiratory failure were selected.According to random number table,patients were assigned to a control group and a study group,each with 34 cases.The control group received conventional anti-infective drugs,and the study group received anti-infective drugs combined with BiPAP non-invasive ventilation.Patients in both groups were compared in terms of heart rate,respiratory rate,arterial blood gas indexes[arterial partial pressure of carbon dioxide(PaCO2),arterial partial pressure of oxygen(PaO2),and blood oxygen saturation(SaO2)],pulmonary function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC]before and after treatment,and the occurrence of adverse reactions.Results After 1 and 2 d of treatment,the heart rate in the study group were(97.42±7.62)and(85.13±4.91)beats/min,and the respiratory rate were(21.72±6.50)and(20.05±4.13)times/min,which were lower than(101.58±9.34),(99.72±7.68)beats/min and(26.97±5.87),(24.97±4.25)times/min in the control group.The difference was statistically significant(P<0.05).After 7 d of treatment,PaCO2 was(44.08±2.67)mm Hg(1 mm Hg=0.133 kPa)in the study group,which was lower than(50.27±3.16)mm Hg in the control group;the study group had PaO2 of(79.14±5.91)mm Hg and SaO2 of(91.98±8.67)%,which were higher than(67.15±5.12)mm Hg and(83.41±8.52)%in the control group;the difference was statistically significant(P<0.05).After 7 d of treatment,the study group had FEV1 of(2.04±0.72)L,FVC of(3.11±0.41)L,FEV1/FVC of(72.47±9.27)%,which were higher than(1.68±0.61)L,(2.67±0.48)L,(64.18±8.26)%in the control group.The difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was 8.82%,which was lower than 29.41%in the control group,and the difference was statistically significant(P<0.05).Conclusion The anti-infective drugs combined with BiPAP non-invasive ventilation has positive significance in elderly patients with respiratory failure,which can effectively improve the clinical symptoms of patients,improve the oxygenation indexes and pulmonary function,and has popularization value.
Respiratory failure in the elderlyAnti-infective drugsBi-level positive airway pressureNon-invasive ventilation
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