Application effect of remimazolam in clinical anesthesia
Objective To explore the application effect of remimazolam in clinical anesthesia.Methods A total of 82 patients requiring thoracoscopic lobectomy were selected and divided into a control group and a study group according to different anesthesia methods,each consisting of 41 patients.The control group was given conventional anesthetic drugs,and the study group was given remimazolam anesthesia.The pain threshold before and after anesthesia induction,electroencephalogram index,peripheral blood superoxide dismutase and malondialdehyde levels were compared between the two groups.Results After anesthesia induction,the pain threshold of the two groups was significantly higher than that before anesthesia induction,and the study group had higher pain threshold of(3.68±0.26)mA than(3.09±0.10)mA of the control group(P<0.05).The peripheral blood superoxide dismutase of(90.74±10.21)U/ml in the study group was higher than(70.86±10.37)U/ml of the control group,and the malondialdehyde of(6.07±1.05)nmol/ml was lower than(7.14±1.25)nmol/ml of the control group(P<0.05).At 10,20 and 30 min after anesthesia induction,the electroencephalogram frequency in both groups was lower than that before anesthesia induction,and the amplitude was higher than that before anesthesia induction(P<0.05).The electroencephalogram frequency and amplitude at 20 min after anesthesia induction in the study group were higher than those in the control group(P<0.05).The electroencephalogram frequency at 30 min after anesthesia induction in the study group was lower than that in the control group,and the amplitude was higher than that in the control group(P<0.05).Conclusion The application of remimazolam sedation has an ideal effect,which can reduce the postoperative acute and chronic pain and reduce the probability of post-traumatic stress reaction,which is worthy of promotion and application.
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