Research progress of miR-29a in cardiovascular diseases
Cardiovascular disease(CVD)is one of the most serious diseases that threaten human health,including acute myocardial infarction(AMI),hypertension,atrial fibrillation(AF),pulmonary arterial hypertension(PAH),hypertrophic cardiomyopathy(HCM)and many other diseases.With the pathophysiological changes of the diseases and the occurrence and development of myocardial fibrosis,myocardial hypertrophy,heart failure and myocardial ischemia,and the cardiac structure is also changed.Finally,the diseases are worsened.miR-29a can participate in the occurrence and development of a variety of CVDs and can play a regulatory role in cardiomyocyte fibrosis and myocardial remodeling.It is a very potential therapeutic target and a promising biomarker.This paper reviews the molecular structure of miR-29a and its role in CVD.
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