Efficacy analysis of adjuvant chemotherapy with Aidi injection in the treatment of advanced non-small cell lung cancer in the elderly
Objective To explore the clinical effect of adjuvant chemotherapy with Aidi injection in the treatment of advanced non-small cell lung cancer in the elderly.Methods 62 elderly patients with advanced non-small cell lung cancer were grouped into a reference group and a study group according to the coin tossing method,each consisting of 31 patients.Patients in the reference group were treated with gemcitabine and cisplatin(GP)chemotherapy,and patients in the study group were treated with Aidi injection based on the reference group.Patients in both groups were compared in terms of threapeutic effect,immune function[CD3+,CD4+,CD8+,CD4+CD25+regulatory T cells(Treg)]and quality of life score(physiological score,psychological score,social score,environmental score).Results The study group had objective effective rate of 45.16%and disease control rate of 87.10%,which were higher than 19.35%and 54.84%of the reference group(P<0.05).After treatment,the study group had CD3+of(55.65±7.86)%and CD4+of(36.29±5.49)%,which were higher than(50.16±8.42)%and(30.49±4.19)%in the reference group;the study group had CD8+of(22.59±4.89)%and CD4+CD25+Treg of(4.36±1.08)%,which were lower than(26.15±4.36)%and(8.15±1.39)%in the reference group(P<0.05).After treatment,the physiological,psychological,social and environmental scores of the study group were(70.33±3.12),(71.44±3.25),(71.64±5.22)and(71.87±4.25)points,which were higher than(60.36±2.25),(60.64±5.15),(60.65±4.22)and(60.64±5.25)points of the reference group(P<0.05).Conclusion Adjuvant chemotherapy with Aidi injection for elderly patients with advanced non-small cell lung cancer can improve the therapeutic effect and quality of life,and improve the immune function.It can be popularized in clinical application.
Aidi injectionChemotherapyAdvanced non-small cell lung cancerImmune functionQuality of lifeOld age
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