Exploring the pregnancy outcome of expectant treatment for early-onset severe preeclampsia complicated with fetal growth restriction
Objective To analyze the pregnancy outcome of expectant treatment for early-onset severe preeclampsia complicated with fetal growth restriction.Methods A total of 60 maternal women with early-onset severe preeclampsia with or without fetal growth restriction were selected.Among them,30 maternal women with combined fetal growth restriction were included in the observation group,while 30 maternal women without combined fetal growth restriction were included in the control group.Both groups were treated with expectant therapy.The maternal complications,perinatal situation,and neonatal complications were compared between the two groups.The perinatal outcomes at different gestational ages in the observation group were compared.Results There were no significant differences between the two groups in terms of incidence of eclampsia,heart failure,placental abruption,simple liver dysfunction,simple thrombocytopenia and HELLP syndrome(P>0.05).The neonatal mortality rate of 20.00%in the observation group was higher than 3.33%in the control group,and the neonatal birth weight of(1294.19±308.30)g was lower than(1599.25±392.28)g in the control group(P<0.05).There were no significant differences in the cesarean section rate,pregnancy termination rate due to fetal factors,and gestational age at delivery between the two groups(P>0.05).The incidence rate of neonatal pulmonary hyaline membrane disease and cardiac hypoplasia were 26.67%and 23.33%in the observation group,which were higher than 3.33%and 0 in the control group(P<0.05).There were no significant differences in the incidence of neonatal sepsis,intracranial hemorrhage and anemia between the two groups(P>0.05).In the observation group,the neonatal mortality rate of perinatal infants at over 32 weeks of gestation was 0,the incidence rate of cardiac hypoplasia was 5.26%,and the incidence rate of neonatal pulmonary hyaline membrane disease was 5.26%,all of which were lower than 66.67%,66.67%and 66.67%of perinatal infants at under 30 weeks of gestation,and 50.00%,50.00%and 62.50%of perinatal infants at 30-31+6 weeks of gestation(P<0.05).Conclusion Implementing expectant treatment for patients with early-onset severe preeclampsia combined with fetal growth restriction will not increase maternal complications and has high safety.Although indicators such as perinatal mortality rate,birth weight,and incidence of complications are poor,the outcome of perinatal infants will improve with the prolongation of gestational age.Therefore,this method has high application value.
Early-onset severe preeclampsiaFetal growth restrictionExpectant treatmentPregnancy outcome
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维普
