Effects of propofol combined with different doses of sufentanil on δ and β band of quantitative pharmaco-electroencephalogram during endotracheal intubation for general anesthesia in adults
Objective To study the effect of different doses of sufentanil combined with propofol on different frequency bands of quantitative pharmaco-electroencephalography(QPEEG)during endotracheal intubation for general anesthesia in adults.Methods A total of 60 patients who were to undergo abdominal surgery under general anesthesia with endotracheal intubation were selected as the study subjects.After guiding the patient into the operating room,routine electrocardiogram monitoring and QPEEG detection were performed.The electroencephalogram signals in different brain regions(left and right frontal,parietal,and temporal lobes)of the patient were collected and divided into multiple frequency bands by the above detection methods,and the induction was carried out with cisatracurium besilate,propofol and sufentanil respectively.According to different doses of sufentanil,it could be divided into group Ⅰ(0.15 μg/kg),group Ⅱ(0.30 μg/kg)and group Ⅲ(0.45 μg/kg),each with 20 cases.When patients in the three groups were under anesthesia,depth of consciousness monitor was used to observe the depth of consciousness.QPEEG signals were collected 1 min before endotracheal intubation(G0)and 1 min after endotracheal intubation(G1)when the Narcotrend indexes were all in the range of 40-60.The need for atropine and pressor drugs during induction of general anesthesia and the percentage change in δ and β band power in each brain region were compared among the three groups.Results In group Ⅰ,the percentage of patients using atropine was 5.00％and no patients using antihypertensive drugs;in group Ⅱ,the percentage of using atropine was 15.00％and the percentage of using pressor drugs was 10.00％;in group Ⅲ,the percentage of using atropine was 40.00％and the percentage of using pressor drugs was 25.00％;The percentage of using atropine and pressor drugs in group Ⅲ was higher than that in group Ⅰ,and the difference reflected statistical significance(P<0.05).Comparison of the percentage of using atropine and pressor drugs between group Ⅰ and group Ⅱ,group Ⅱ and group Ⅲ,and the difference did not reflect statistical significance(P>0.05).Compared with G0,the percentage of β-band power of all brain regions at G1 of the three groups increased significantly,and the difference reflected statistical significance(P<0.05),among which the most obvious changes were in the left frontal,right and left parietal,and right and left temporal brain regions;comparison of the percentage of β-band power of all brain regions at G1 among the three groups showed statistically significant differences(P<0.05),with group Ⅰ>group Ⅱ>group Ⅲ,and among which the most significant region was the left frontal,parietal brain regions.Compared with G0,the percentage of δ-band power decreased in all brain regions at G1 in the three groups,with the most obvious regions being the left frontal,right and left parietal brain regions;the difference in the percentage of δ-band power in the left frontal brain region of the three groups at G1 reflected statistical significance(P<0.05),with group Ⅰ and group Ⅱ<group Ⅲ;the comparison of the remaining brain regions among the three groups was not different and did not reflect statistical significance(P>0.05).Conclusion Under the same sedation effect,nociceptive stimulation can promote the changes of brain waves,and the percentage of β-band power will increase significantly,while the percentage of δ-band power should decrease significantly.Therefore,there is a very obvious correlation between the changes of brain electricity and nociceptive stimulation in the above two bands,and the changes of EEG in the β-band can be suppressed in the application of high-dose sufentanil.
万方数据
维普
