Analysis of the effectiveness of aspirin combined with clopidogrel bisulfate in the treatment of cerebral infarction
Objective To explore the effectiveness of aspirin combined with clopidogrel bisulfate in the treatment of cerebral infarction.Methods 240 patients with cerebral infarction were divided into an observation group and a control group according to the principle of double-blind method,each with 120 cases.Patients in the control group were treated with aspirin orally,and patients in the observation group were treated with aspirin combined with clopidogrel bisulfate orally.Comparison was made on treatment effect,activated partial prothrombin time,prothrombin time,thrombin time,fibrinogen,platelet aggregation rate,National Institutes of Health Stroke Scale(NIHSS)score and Barthel index,and the incidence of adverse reactions between the two groups.Results The total clinical effective rate of the observation group and the control group were 98.33%and 85.00%,and the total clinical effective rate of the observation group was at a higher level(P<0.05).After treatment,the level of fibrinogen of(2.41±0.43)g/L in the observation group was lower than(3.85±0.64)g/L in the control group(P<0.05).The activated partial prothrombin time,prothrombin time and thrombin time in the observation group were(35.48±2.21),(13.19±1.53)and(20.45±2.24)s,which were longer than(30.47±2.15),(10.83±1.27)and(16.75±1.87)s in the control group(P<0.05).Before treatment,there was no significant difference in platelet aggregation rate between the two groups(P>0.05).After 2 and 4 weeks of treatment,the platelet aggregation rate decreased significantly in both groups;the platelet aggregation rate in the observation group were(33.22±4.47)%and(37.13±4.26)%,which were lower than(40.78±4.75)%and(43.67±4.39)%in the control group(P<0.05).Before treatment,there were no significant differences in NIHSS score and Barthel index between the two groups(P>0.05).After treatment,the NIHSS score of both groups decreased,and the Barthel index score increased significantly;NIHSS score and Barthel index score were(10.23±1.04)and(72.53±5.46)points,which were better than(17.72±1.28)and(60.78±4.35)points of the control group(P<0.05).After different treatment regimens,the incidence of adverse reactions in the observation group and the control group were 3.33%and 14.17%,and the incidence of adverse reactions in the observation group was lower(P<0.05).Conclusion Oral administration of aspirin and clopidogrel bisulfate in patients with cerebral infarction can significantly enhance the clinical efficacy,reduce the platelet aggregation rate,improve the patients'coagulation index,neurological function and daily activities,and effectively reduce the occurrence of adverse reactions.
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