Effect of enteral nutrition combined with probiotics on the level of serum inflammatory factors in the treatment of patients with severe pneumonia and its influence on their serum inflammatory factor levels
Objective To explore the the clinical effect of enteral nutrition intervention combined with probiotics in the treatment of patients with severe pneumonia,and observe its influence on serum inflammatory factors and prognosis of patients.Methods 56 patients with severe pneumonia were selected and divided into a control group(n=28,conventional treatment and enteral nutrition intervention)and a study group(n=28,conventional treatment+enteral nutrition intervention combined with probiotics)by random number table method.Both groups were compared in terms of therapeutic effect,serum inflammatory factors[white blood cell count(WBC),procalcitonin(PCT),interleukin-6(IL-6),C-reactive protein(CRP)]and lung function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC].Results The total effective rate of 96.43%in the study group was higher than 71.43%in the control group(P<0.05).After treatment,WBC,PCT,IL-6 and CRP were decreased in both groups;the study group had WBC of(7.12±0.64)×109/L,PCT of(0.71±0.16)ng/ml,IL-6 of(75.11±6.34)ng/L and CRP of(5.16±0.45)mg/L,which were all lower than(9.25±0.55)×109/L,(1.05±0.21)ng/ml,(85.23±6.76)ng/L and(8.52±1.05)mg/L in the control group(P<0.05).After treatment,FEV1,FVC and FEV1/FVC were improved in both groups;the study group had FEV1 of(3.21±0.57)L,FVC of(3.59±0.24)L and FEV1/FVC of(74.36±5.34)%,which were higher than(2.34±0.63)L,(3.05±0.43)L and(68.24±4.12)%in the control group(P<0.05).Conclusion For patients with severe pneumonia,enteral nutrition intervention combined with probiotics can improve the nutritional level,reduce the level of serum inflammatory factors,improve the lung function of patients,and significantly improve the therapeutic effect,thus promoting the recovery of patients.
Severe pneumoniaEnteral nutritionProbioticsLung functionSerum inflammatory factors
万方数据
维普
