Clinical study on the combination of Baibai Kanglao Granules and 2HRZE/4HR in the treatment of active pulmonary tuberculosis
Objective To explore the clinical effect of combination of Baibai Kanglao Granules and 2HRZE/4HR in the treatment of active pulmonary tuberculosis.Methods 86 cases of patients with active pulmonary tuberculosis were selected as the research subjects.They were randomly divided into a control group and an observation group,with 43 cases in each group.The control group received anti tuberculosis treatment with the 2HRZE/4HR regimen,while the observation group received anti-tuberculosis treatment with the combination of Baibai Kanglao Granules and 2HRZE/4HR regimen.The clinical efficacy,negative sputum conversion rate,symptom improvement time and incidence of adverse reactions were compared between the two groups.Results The total effective rate of 95.35%in the observation group was significantly higher than 81.40%in the control group(P<0.05).There was no significant difference in sputum negative conversion rate between the two groups after 1 month of treatment(P>0.05).The sputum negative conversion rates in the observation group were 88.37%and 95.35%after 3 and 6 months,which were higher than 69.77%and 81.40%in the control group(P<0.05).The remission time of cough and sputum in the observation group were(8.84±2.36)d and(9.86±2.32)d,which were significantly shorter than(11.26±2.52)and(12.86±2.85)d in the control group(t=4.596,5.435;P=0.000,0.000<0.05).The incidence of adverse reactions was 25.58%(11/43)in the observation group,which had no significant difference compared with 30.23%(13/43)in the control group(P>0.05).Conclusion The combination of Baibai Kanglao Granules and 2HRZE/4HR regimen can significantly improve the treatment effect of active pulmonary tuberculosis,shorten the time for symptom improvement,and have good safety,which is worthy of promotion and application.
Active pulmonary tuberculosisBaibai Kanglao Granules2HRZE/4HR regimen
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维普
