Analysis of clinical value of modified Zhishi Xiaopi pill in treating diabetic gastroparesis
Objective To analyze the effect of modified Zhishi Xiaopi pill in treating diabetic gastroparesis(DGP).Methods 80 patients with DGP were divided into a traditional group and a treatment group according to dice-rolling method,with 40 cases in each group.The traditional group was treated with domperidone,and the treatment group was treated with modified Zhishi Xiaopi pill.The efficacy,gastrointestinal hormone indexes(gastrin,motilin and somatostatin),gastric emptying and adverse reactions were compared between the two groups.Results The total effective rate of 97.50%in the treatment group was higher than 82.50%in the traditional group(χ2=5.0000,P=0.0253<0.05).After treatment,the motilin and gastrin in both groups were higher than those before treatment,while the somatostatin was lower than that before treatment(P<0.05).After treatment,the treatment group had motilin of(351.62±18.76)pg/ml and gastrin of(69.82±4.52)pg/ml,which were higher than(332.49±17.03)and(64.11±3.08)pg/ml in the traditional group;the somatostatin of(12.09±2.11)ng/ml in the treatment group was lower than(20.97±6.13)ng/ml in the traditional group(P<0.05).After treatment,the gastric emptying time in both groups was shorter than that before treatment,and the gastric emptying rate was higher than that before treatment(P<0.05).After treatment,the gastric emptying time of(2.98±0.65)h in the treatment group was shorter than(4.01±0.77)h in the traditional group,and the gastric emptying rate of(72.96±5.03)%was higher than(55.31±8.92)%in the traditional group(P<0.05).The incidence of adverse reaction of 5.00%in the treatment group was lower than 20.00%in the traditional group(χ2=4.1143,P=0.0425<0.05).Conclusion Modified Zhishi Xiaopi pill has high total effective rate in the treatment of DGP,which can shorten the gastric emptying time,maintain a high gastric emptying rate,improve gastrointestinal motility,and reduce adverse reactions,thus promoting the rehabilitation of patients.
万方数据
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