Observation on the curative effect of Yishen Bupi Decoction on stage Ⅳ diabetic kidney disease
Objective To study and explore the curative effect of Yishen Bupi Decoction on stage Ⅳ diabetic kidney disease.Methods 50 patients with stage Ⅳ diabetic kidney disease were divided into a control group and a study group according to random number table method,with 25 cases in each group.The control group was treated with conventional Western medicine,and the study group was treated with Yishen Bupi Decoction on the basis of the control group.Both groups were compared in terms of blood glucose indicators(fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin),renal function indicators(serum creatinine,urea nitrogen,urinary albumin to creatinine ratio,glomerular filtration rate),quality of life,and occurrence of adverse reactions.Results After treatment,the fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin in both groups were significantly reduced compared with those before treatment;in the study group,the fasting blood glucose was(5.45±0.83)mmol/L,the 2 h postprandial blood glucose was(8.56±0.97)mmol/L and the glycosylated hemoglobin was(5.29±0.54)％,which were lower than(6.95±0.92)mmol/L,(10.69±1.05)mmol/L and(6.03±0.67)％in the control group(P<0.05).After treatment,the serum creatinine,urea nitrogen,urinary albumin to creatinine ratio in both groups were lower than those before treatment,and the glomerular filtration rate was higher than that before treatment;the study group had serum creatinine of(82.05±7.39)μmol/L,urea nitrogen of(6.14±0.89)mmol/L,urinary albumin to creatinine ratio of(10.64±1.59)mg/mmol,which were lower than(90.43±8.07)μmol/L,(7.03±0.97)mmol/L,(12.50±1.87)mg/mmol in the control group;the glomerular filtration rate of(119.05±5.46)ml/min in the study group was higher than(113.24±5.07)ml/min in the control group(P<0.05).After treatment,the physiological,psychological,environmental,and social relationship scores in both groups were increased compared with those before treatment;in the study group,the physiological score was(89.75±6.48)points,the psychological score was(89.07±6.02)points,the environmental score was(90.14±6.15)points,and the social relationship score was(89.96±6.27)points,which were higher than(82.93±6.85),(82.40±6.13),(83.27±6.30),and(83.14±6.54)points in the control group(P<0.05).After treatment,there was no significant difference in incidence of adverse reactions between the study group and the control group(P>0.05).Conclusion In the treatment of patients with stage Ⅳ diabetic kidney disease,the application of conventional Western medicine regimen combined with Yishen Bupi Decoction can enhance the therapeutic efficacy and better improve the patients'blood glucose level and renal function,and the application of this treatment program has fewer adverse reactions and good safety.
Stage Ⅳ diabetic kidney diseaseIntegrated traditional Chinese and Western medicine therapyYishen Bupi DecoctionTraditional Chinese medicine
万方数据
维普
