Effect analysis of tirofiban on ischemic cerebrovascular disease
Objective To analyze the clinical effect of tirofiban on ischemic cerebrovascular disease.Methods 100 patients with ischemic cerebrovascular disease were divided into a control group and an observation group by random number table method,with 50 cases in each group.The control group was treated with conventional thrombolytic therapy,and the observation group was treated with tirofiban on the basis of the control group.The clinical efficacy,incidence of adverse reactions,quality of life and neurological function were compared between the two groups.Results At 72 h after treatment,there was no significant difference in rate of disease progression between the observation group and the control group(P>0.05).At 1 week after treatment,the rate of disease progression of 4.00%in the observation group was significantly lower than 18.00%in the control group(P<0.05).After 1 week of follow-up,the incidence of adverse reactions of 8.00%in the observation group was significantly lower than 24.00%in the control group(P<0.05).Before treatment,there were no significant differences in the scores of social function,psychological function and physical function between the two groups(P>0.05).After treatment,the scores of social function,psychological function and physical function in the observation group were(80.56±7.22),(74.30±7.13)and(77.26±7.35)points,which were significantly higher than(60.71±8.28),(63.51±6.05)and(64.45±7.26)points in the control group(P<0.05).Before treatment,there was no significant difference in the National Institutes of Health Stroke Scale(NIHSS)score between the two groups(P>0.05).At 72 h and 1 week after treatment,the NIHSS scores of the observation group were(4.18±1.45)and(3.60±1.05)points,which were lower than(8.26±1.84)and(6.42±1.71)points of the control group(P<0.05).Conclusion Tirofiban treatment in patients with ischemic cerebrovascular disease can stabilize the condition,reduce the incidence of adverse reactions,improve the quality of life of patients during treatment,and greatly improve the neurological function of patients.
TirofibanIschemic cerebrovascular diseaseThrombolysisNeurological function
NETL
NSTL
万方数据
