Effect of etomidate combined with remifentanil in anesthesia for pediatric congenital anal atresia surgery
Objective To explore the effect of etomidate combined with remifentanil in anesthesia for pediatric congenital anal atresia surgery.Methods A total of 60 pediatric patients with congenital anal atresia who underwent surgical treatment were randomly divided into a control group and a study group using a random number table method,with 30 cases in each group.The control group received ketamine anesthesia during surgery,while the study group received etomidate combined with remifentanil anesthesia during surgery.The anesthesia effect,sedation score,pain score,intraoperative vital sign indicators,postoperative anesthesia recovery time,and incidence of postoperative adverse reactions were compared between the two groups.Results The excellent rate of anesthesia of 100.00%in the study group was higher than 86.67%in the control group(P<0.05).The study group had higher sedation score of(3.45±0.52)points than(2.76±0.49)points in the control group,and lower pain score of(1.68±0.55)points than(2.54±0.71)points in the control group(P<0.05).Before anesthesia induction,there were no significant differences in mean arterial pressure and heart rate between the two groups(P>0.05).After intubation and 1 min after incision,the mean arterial pressure and heart rate of the study group had no significant difference compared with that before anesthesia induction(P>0.05),while the mean arterial pressure and heart rate of the control group were increased compared with that before anesthesia induction(P<0.05).After intubation and 1 min after incision,the mean arterial pressure and heart rate of the study group were(56.75±2.27),(56.49±2.42)mm Hg(1 mm Hg=0.133 kPa)and(151.68±3.12),(151.37±3.28)beats/min,which were lower than(62.98±3.09),(59.56±2.61)mm Hg and(159.45±3.39),(155.31±3.47)beats/min of the control group(P<0.05).The postoperative spontaneous breathing recovery time,eye opening time,and command recovery time of the study group were(7.89±2.82),(9.04±2.45),and(16.85±3.10)min,which were shorter than(12.65±3.49),(13.91±3.57),and(21.42±3.37)min of the control group(P<0.05).There was no significant difference in the incidence of postoperative adverse reactions between the two groups(P>0.05).Conclusion In the surgery of congenital anal atresia in children,the application of etomidate combined with remifentanil can not only enhance the surgical anesthesia effect of patients,play a good sedative and analgesic role,maintain stable intraoperative vital signs,but also shorten the postoperative recovery time,with both effective and safe anesthesia.
NewbornsCongenital anal atresiaSurgeryTracheal intubation under general anesthesiaEtomidateRemifentanil
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