Analysis of clinical value of HE4,CA125 and CA153 in the diagnosis of benign ovarian tumors
Objective To study the clinical value of serum human epididymal protein 4(HE4),carbohydrate antigen 125(CA125)and carbohydrate antigen 153(CA153)in the diagnosis of benign ovarian tumors.Methods A total of 41 patients with benign ovarian tumors were selected as the study subjects.They were divided into endometriosis group(n=18)and other benign ovarian tumors group(n=23)according to the difference of pathological examination results.Serum levels of HE4,CA125 and CA153 were detected and compared between the two groups.The efficacy of serum HE4,CA125 and CA153 levels in the diagnosis of endometriosis was analyzed by receiver operating characteristic(ROC)curve.The serum levels of HE4,CA125 and CA153 were compared between the two groups before and after surgery.Pearson correlation analysis was used to determine the correlation of serum HE4,CA125 and CA153 levels in patients with endometriosis.Results The serum levels of HE4,CA125 and CA153 in endometriosis group were(115.10±12.73)pmol/L,(46.71±6.29)U/ml and(28.58±4.60)U/ml,which were higher than(86.97±10.30)pmol/L,(38.63±4.80)U/ml and(16.83±3.01)U/ml of other benign ovarian tumors group(P<0.05).ROC curve analysis confirmed that the sensitivity,Youden's index,and area under the curve of combined diagnosis of serum HE4,CA125 and CA153 levels was better than that of the above three indicators alone.The serum levels of HE4,CA125 and CA153 in endometriosis group and other benign ovarian tumor groups were lower after surgery were lower than those before surgery(P<0.05).Pearson correlation analysis showed that there was a positive correlation between serum HE4 and CA125,HE4 and CA153,and CA125 and CA153 in patients with endometriosis(r=0.735,0.766,0.801;P<0.05).Conclusion Serum HE4,CA125 and CA153 levels are of high value in the diagnosis of benign ovarian tumors,which is conducive to the differential diagnosis of endometriosis and other benign ovarian tumors,and may have certain value in evaluating the efficacy.
Benign ovarian tumorsEndometriosisHuman epididymal protein 4Carbohydrate antigen 125Carbohydrate antigen 153
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