Analysis of the value of carotid ultrasound and contrast-enhanced ultrasound combined with serum adiponectin and hypersensitive C-reactive protein in atherosclerotic cerebral infarction
Objective To analyze the clinical value of carotid ultrasound and contrast-enhanced ultrasound combined with adiponectin and hypersensitive C-reactive protein in atherosclerotic cerebral infarction.Methods 66 patients with atherosclerotic cerebral infarction were selected as the study group,and another 66 healthy subjects were selected as the conventional group.Carotid ultrasound and contrast-enhanced ultrasound were performed in the two groups to determine the type and grade of atherosclerotic plaque.Enzyme-linked immunosorbent assay and immunoturbidimetric assay were used to detect serum adiponectin and hypersensitive C-reactive protein.The serum adiponectin and hypersensitive C-reactive protein levels were compared between the conventional group and the study group,and the detection results of carotid ultrasound and contrast-enhanced ultrasound were analyzed.The serum adiponectin and hypersensitive C-reactive protein levels of patients with different plaque types and patients with different levels of neovascularization in soft plaques were compared.Results The study group had lower serum lipocalin level of(472.76±44.78)μg/ml than(750.59±30.41)μg/ml in the conventional group,and higher hypersensitive C-reactive protein level of(10.93±2.87)mg/L than(5.01±1.08)mg/L in the conventional group(P<0.05).Regarding the results of carotid ultrasound,plaque was detected in 46 patients in the study group,with a detection rate of 69.70%(46/66),in which there were 30 cases of hard plaques and 16 cases of soft plaques.In patients with hard plaques,the serum lipocalin level of(580.85±132.69)μg/ml was higher than(394.01±115.24)μg/ml in patients with soft plaques,and the serum ultrasensitive C-reactive protein level of(11.13±2.81)mg/L was lower than(13.18±2.67)mg/L in patients with soft plaques(P<0.05).As for the results of carotid ultrasound,further contrast-enhanced ultrasound was performed in 16 patients with soft plaques to grade the neovascularization within the plaque,with a total of 6 cases of grade 1 and grade 2 plaques,and a total of 10 cases of grade 3 and grade 4 plaques.Among patients with grade 3 and grade 4 plaques,the serum adiponectin level of(318.87±112.04)μg/ml was lower than(519.46±118.48)μg/ml of patients with grade 1 and grade 2 plaques,and the hypersensitive C-reactive protein of(14.34±2.85)mg/L was higher than(11.00±1.56)mg/L of grade 1 and grade 2 plaques(P<0.05).Conclusion The type of carotid atherosclerotic plaque is closely related to the occurrence of cerebral infarction,and the serum levels of adiponectin and hypersensitive C-reactive protein are closely related to the stability of cerebral infarction and plaque.Carotid ultrasound and contrast-enhanced ultrasound combined with serum adiponectin and hypersensitive C-reactive protein levels can help to evaluate the risk of cerebral infarction and guide clinical prevention and treatment.
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