Exploration of the efficacy and prognostic value of serum CD121a level for acute myocardial infarction undergoing PCI
Objective To explore the efficacy and prognostic value of serum interleukin 1 receptor type 1(IL-1R1,also known as CD121a)level for acute myocardial infarction(AMI)undergoing percutaneous coronary intervention(PCI).Methods 30 patients with AMI who underwent PCI were selected as the AMI group,and another 30 subjects with completely normal coronary angiography were selected as the control group.In the AMI group,serum CD121a levels were measured before PCI,on the 2nd day after surgery,and at 1 week after surgery;in the control group,serum CD121a levels were measured before coronary angiography.After discharge,patients in the AMI group will undergo 1-year outpatient follow-up or telephone follow-up for whether major adverse cardiovascular events(MACE)occurred or not,and will be grouped(with or without MACE)according to the follow-up results.Comparison of clinical data(prevalence of hypertension,diabetes mellitus,smoking,and alcohol consumption)and lipid indices(total cholesterol,triglycerides,low-density lipoprotein cholesterol,and high-density lipoprotein cholesterol),three items of myocardial infarction[creatine kinase isoenzyme,cardiac troponin I(cTnI),and myoglobin],inflammation indices[high-sensitivity C-reactive protein(hs-CRP)],and markers of heart failure[N-terminal pro-B-type natriuretic peptide(NT-proBNP)]between AMI group and control group.Comparison of serum CD121a levels between the control group and AMI group(before PCI,on the 2nd day after surgery,and at 1 week after surgery).Comparison of serum CD121a levels between MACE patients and non-MACE patients.Results In AMI group,the diabetes mellitus accounted for 26.7%,the alcohol consumption accounted for 36.7%,the total cholesterol was(4.97±1.27)mmol/L,the low density lipoprotein cholesterol was(3.45±1.18)mmol/L,the creatine kinase isoenzyme was(179.16±88.07)U/L,cTnI was(10.31±3.88)ng/ml,the myoglobin was(394.99±78.27)ng/ml,hs-CRP was(13.39±5.13)mg/L,and NT-proBNP was(600.72±96.22)pg/ml,which were significantly higher than 3.3%,13.3%,(4.04±0.78)mmol/L,(2.46±0.66)mmol/L,(9.90±4.33)U/L,(0.10±0.01)ng/ml,(15.50±2.44)ng/ml,(3.88±0.54)mg/L,and(87.85±16.05)pg/ml in the control group(P<0.05).There was no statistically significant difference in the comparison of hypertension,smoking percentage and high density lipoprotein cholesterol and triglyceride levels between the two groups(P>0.05).The CD121a levels in the AMI group were(2387.68±537.75),(2005.73±534.96)and(1670.23±441.83)pg/ml before PCI,on the 2nd day after surgery and at 1 week after surgery,which was significantly higher than(1356.67±372.69)pg/ml in the control group(P<0.05).The level of serum CD121a in AMI group on the 2nd day and at 1 week after PCI was lower than that before PCI(P<0.05),and the level of serum CD121a at 1 week after PCI was significantly lower than that on the 2nd day after PCI(P<0.05).Patients with AMI were followed up for 1 year,8 patients developed MACE and 22 patients did not develop MACE.The serum CD121a level was(2826.82±533.82)pg/ml in patients with MACE,which was significantly higher than(2227.97±451.82)pg/ml in patients without MACE(P<0.05).Conclusion Serum CD121a level is valuable for evaluating the efficacy of AMI patients after PCI and predicting the long-term adverse prognosis.
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