The effect of argatroban combined with aspirin on serum inflammatory factors and nerve damage in patients with acute cerebral infarction
Objective To explore the effect of argatroban combined with aspirin on serum inflammatory factors and nerve damage in patients with acute cerebral infarction.Methods 68 patients with acute cerebral infarction were selected and divided into a control group(34 cases)and an observation group(34 cases)using a random number table method.The control group was treated with aspirin,while the observation group was treated with argatroban on the basis of the control group.Comparison was made on the levels of serum inflammatory factors[matrix metalloproteinase-9(MMP-9),tumor necrosis factor-α(TNF-α),lipoprotein-associated phospholipase A2(Lp-PLA2)],vascular endothelial function[nitric oxide(NO),endothelin-1(ET-1),and flow-mediated dilation(FMD)]level,degree of neurological damage[National Institutes of Health Stroke Scale(NIHSS)score],and occurrence of adverse reactions between the two groups.Results After treatment,the levels of MMP-9,TNF-α and Lp-PLA2 in both groups were lower than those before treatment;the observation group had MMP-9 of(137.52±3.67)μg/L,TNF-α of(7.59±0.52)μg/L,and Lp-PLA2 of(12.83±1.54)pg/ml,which were lower than(165.72±4.83)μg/L,(11.28±0.93)μg/L,and(17.64±1.93)pg/ml in the control group;the difference was statistically significant(P<0.05).After treatment,NO and FMD in both groups were higher than those before treatment,and ET-1 was lower than that before treatment;the observation group had NO of(65.73±8.56)μmol/L and FMD of(13.46±2.35)%,which were higher than(53.62±7.42)μmol/L and(10.84±1.72)%in the control group;ET-1 of(52.71±4.32)ng/L in the observation group was lower than(68.92±5.67)ng/L in the control group;the difference was statistically significant(P<0.05).After treatment,the NIHSS score in both groups was lower than that before treatment;the NIHSS score of(16.53±2.14)points in the observation group was lower than(22.61±2.87)points in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined use of argatroban and aspirin in patients with acute cerebral infarction can effectively improve the levels of inflammatory factors and vascular endothelial function,and reduce the degree of nerve damage in patients,with good safety.
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