Observation on clinical effect of dapagliflozin combined with conventional anti-heart failure drugs in the treatment of patients with chronic heart failure
Objective To explore the clinical efficacy of dapagliflozin combined with conventional anti-heart failure drugs(furosemide,spironolactone,metoprolol sustained-release tablets,sacubitril valsartan sodium)in the treatment of patients with chronic heart failure.Methods 84 patients with chronic heart failure were studied and divided into a control group and an observation group by simple random method,with 42 cases in each group.The control group was treated with conventional anti-heart failure drugs(furosemide,spironolactone,metoprolol sustained-release tablets,sacubitril valsartan sodium),while the observation group was treated with dapagliflozin tablets on the basis of the control group.Both groups were compared in terms of clinical efficacy,cardiac function indicators[left ventricular ejection fraction(LVEF)and left ventricular end-diastolic diameter(LVEDD)],inflammatory indicators[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]and incidence of adverse reactions.Results Compared with the control group(81.0%),the total clinical effective rate of the observation group(97.6%)was significantly higher(P<0.05).After treatment,the observation group had significantly higher LVEF of(49.62±4.81)%than(40.53±4.55)%in the control group,and significantly lower LVEDD of(52.19±2.09)mm than(63.68±2.33)mm in the control group.The differences were statistically significant(P<0.05).After treatment,the serum levels of IL-6 and TNF-α were(33.32±4.31)and(12.27±2.09)ng/L in the observation group,which were significantly lower than(56.92±5.38)and(35.85±4.63)ng/L in the control group(P<0.05).Compared with the control group(7.1%),the incidence of adverse reactions in the observation group(4.8%)had no significant difference(P>0.05).Conclusion In chronic heart failure patients,the combination of conventional anti-heart failure drugs and dapagliflozin tablets has significant clinical efficacy,and the cardiac function indicators and inflammatory response in the body has been effectively improved,and the safety of joint use of drugs is good,which is worthy of clinical promotion.
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