Effect of enhanced external counterpulsation on levels of inflammatory cytokines IL-1,TNF-α and IL-6 in patients with coronary heart disease
Objective To analyze the effect of enhanced external counterpulsation on levels of inflammatory cytokines interleukin(IL)-1,tumor necrosis factor-α(TNF-α)and IL-6 in patients with coronary heart disease.Methods 40 patients with coronary heart disease were randomly divided into a study group and a control group,with 20 patients in each group.The control group received conventional treatment,and the study group received enhanced external counterpulsation on the basis of conventional treatment.The therapeutic effect and levels of IL-1,TNF-α and IL-6 were compared between the two groups.Results After treatment,the percentage of remission of angina pectoris of the study group was 85.0%,the percentage of increased exercise tolerance was 75.0%,the percentage of remission of angina pectoris and increased exercise tolerance was 50.0%,which were significantly higher than 50.0%,35.0%and 15.0%of the control group(P<0.05).In the control group,there were no significant differences in serum IL-1,IL-6 and TNF-α before and after treatment(P>0.05).After treatment,the levels of IL-1,IL-6 and TNF-α were(6.08±0.53),(4.61±0.33)and(185.62±10.03)pg/ml in the study group,which were significantly lower than(13.51±0.94),(6.91±0.26)and(269.41±11.98)pg/ml before treatment in this group,and(12.61±1.17),(6.17±1.54)and(264.24±12.22)pg/ml after treatment in the control group(P<0.05).Conclusion Enhanced extracorporeal counterpulsation can reduce the expression of serum inflammatory factors in patients with coronary heart disease,which is helpful in inhibiting inflammatory response and alleviating myocardial ischemia,and is worth popularizing.
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