Exploring the clinical efficacy of acetylcysteine effervescent tablets combined with bi-level positive airway pressure ventilator in the treatment of patients with chronic obstructive pulmonary disease complicated with OSAHS
Objective To explore the effect of acetylcysteine effervescent tablets combined with bi-level positive airway pressure(BiPAP)ventilator in the treatment of patients with chronic obstructive pulmonary disease(COPD)complicated with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods 71 patients with COPD complicated with OSAHS were selected as the study subjects.They were randomly divided into an observation group(36 cases)and a control group(35 cases).Patients in the control group were treated with BiPAP ventilator,those in the observation group were treated with a combination of acetylcysteine effervescent tablets and BiPAP ventilator.Patients in both groups were compared in terms of clinical efficacy,pulmonary function indicators[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC],blood gas analysis[arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)],apnea hypopnea index(AHI),inflammation related indicators[interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)].Results The total effective rate of 88.89%in the observation group was significantly higher than 65.71%in the control group(P<0.05).The observation group had FEV1 of(2.03±0.34)L,FVC of(2.86±0.11)L,and FEV1/FVC of(83.17±4.85)%,which were significantly higher than(1.72±0.27)L,(2.13±0.36)L,and(67.27±3.56)%in the control group(P<0.05).The observation group had PaO2 of(89.52±4.75)mm Hg(1 mm Hg=0.133 kPa),PaCO2 of(41.35±2.03)mm Hg and AHI of(10.86±1.48)times/h,which were better than(80.37±4.54)mm Hg,(43.36±3.55)mm Hg and(35.25±5.50)times/h in the control group(P<0.05).The observation group had IL-6 of(9.62±1.45)pg/ml,CRP of(13.15±2.47)mg/L and PCT of(0.05±0.08)ng/ml,which were significantly lower than(18.13±3.21)pg/ml,(22.32±4.28)mg/L and(0.08±0.02)ng/ml in the control group(P<0.05).Conclusion The combination of acetylcysteine effervescent tablets and BiPAP ventilator is highly effective in the treatment of patients with COPD and OSAHS,and is worthy of promotion.
NETL
NSTL
万方数据
