The effect of nifedipine combined with magnesium sulfate on blood pressure and pregnancy outcome of pregnant women with pregnancy induced hypertension
Objective To explore the effect of nifedipine combined with magnesium sulfate on blood pressure and pregnancy outcome of pregnant women with pregnancy induced hypertension.Methods 100 patients with pregnancy induced hypertension were selected as the research subjects,and they were divided into the control group and the observation group according to the random number table method,each consisting of 50 cases.The control group was given magnesium sulfate by intravenous drip,and the observation group took nifedipine orally on the basis of the control group.Comparison was made on treatment effect,blood pressure(systolic blood pressure,diastolic blood pressure),renal function indicators(24 h urinary creatinine,24 h urinary protein quantitation)and incidence of adverse pregnancy outcome between the two groups.Results The total effective rate of 90%in the observation group was significantly higher than 72%in the control group(P<0.05).After 7 d of treatment,the diastolic blood pressure and systolic blood pressure were decreased in both groups;the diastolic blood pressure and systolic blood pressure in the observation group were(77.9±3.6)and(124.5±7.8)mm Hg(1 mm Hg=0.133 kPa),which were lower than(85.5±4.2)and(135.7±9.3)mm Hg in the control group;the differences were significant(P<0.05).Before treatment,the 24 h urinary creatinine and 24 h urinary protein quantitation were not significantly different between the two groups(P>0.05).After treatment,the 24 h urinary creatinine and 24 h urinary protein quantitation decreased in both groups;the 24 h urinary creatinine content and 24 h urinary protein quantitation in the observation group were(5.73±1.16)mmol and(1.55±0.71)g,which were lower than(8.49±1.72)mmol and(2.37±0.83)g in the control group;the difference was significant(P<0.05).The incidence of adverse pregnancy outcome was 14%in the observation group,which was significantly lower than 40%in the control group,and the difference was significant(P<0.05).Conclusion Nifedipine combined with magnesium sulfate in patients with pregnancy induced hypertension can play a synergistic role,improve blood pressure while reducing the risk of hypoxia,thus optimizing the maternal and infant outcomes.
NETL
NSTL
万方数据
