Efficacy of laparoscopic assisted and open D2 radical gastrectomy on advanced gastric cancer in the elderly
Objective To explore the efficacy of laparoscopic assisted and open D2 radical gastrectomy on advanced gastric cancer in the elderly.Methods 100 elderly patients with advanced gastric cancer were selected as study subjects,and divided into a control group(50 patients,open D2 radical gastrectomy)and an observation group(50 patients,laparoscopic assisted D2 radical gastrectomy)according to randomized hospitalization number.Both groups were compared in terms of clinical indicators[intraoperative blood loss,operation time,hospitalization time,first ambulation time,first anal exhaust time,visual analog scale(VAS)score],treatment effect,complications,inflammatory indicators[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interferon-γ(IFN-γ),and transforming growth factor-β(TGF-β)].Results The intraoperative blood loss of(215.89±24.20)ml in the observation group was less than(346.45±26.24)ml in the control group;in the observation group,the operation time was(212.31±24.45)min,the hospitalization time was(10.44±4.23)d,the first ambulation time was(3.09±1.01)d,and the first anal exhaust time was(2.89±0.80)d,which were shorter than(257.81±25.81)min,(14.35±4.23)d,(4.94±1.21)d,and(4.25±1.21)d in the control group;VAS score of(2.69±0.84)points in the observation group was lower than(4.75±1.22)points in the control group;the difference was significant(P<0.05).The total effective rate of 98.00%in the observation group was higher than 86.00%in the control group,and the difference was significant(P<0.05).The incidence of postoperative complications of 2.00%in the observation group was lower than 16.00%in the control group,and the difference was significant(P<0.05).After treatment,the observation group had TNF-α of(133.24±9.33)ng/ml and IL-6 of(362.48±18.04)pg/ml,which were lower than(171.95±9.22)ng/ml and(409.16±18.42)pg/ml in the control group,and the difference was significant(P<0.05).Comparison of IFN-γ and TGF-β between the two groups was balanced(P>0.05).Conclusion For elderly patients with advanced gastric cancer,the treatment of laparoscopic assisted and open D2 radical gastrectomy can improve the treatment effect and recovery effect of patients,facilitate the reduction of complications,and promote the faster recovery of patients'diseases,with remarkable effects.
LaparoscopyD2 radical gastrectomyOpen surgeryAdvanced gastric cancer in the elderlyEffect
万方数据
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