Study on clinical efficacy of ulinastatin combined with early blood perfusion in the treatment of severe acute pancreatitis
Objective To explore the effect of ulinastatin combined with early blood perfusion in the treatment of severe acute pancreatitis.Methods 60 patients with severe acute pancreatitis were divided into a research group and a control group using a random number table method,with 30 patients in each group.The control group was treated with ulinastatin,while the research group was treated with early blood perfusion based on the control group.Comparison was made on therapeutic effect,serum inflammatory factors,symptom score,immune function indicators,and quality of life scores before and after treatment between the two groups.Results The total effective rate of 96.67%in the study group was higher than 80.00%in the control group(P<0.05).After treatment,the levels of C-reactive protein(CRP),procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)in both groups were lower than those before treatment;the research group had CRP of(5.89±1.06)mg/L,PCT of(0.46±0.15)ng/ml,and TNF-α of(10.83±2.07)ng/L,which were lower than(7.02±1.27)mg/L,(0.69±0.23)ng/ml,and(13.49±2.46)ng/L in the control group(P<0.05).After treatment,the scores of abdominal pain,fever,nausea and vomiting in both groups were significantly lower than those before treatment;in the research group,the abdominal pain score was(1.17±0.39)points,the fever score was(1.06±0.31)points,and the nausea and vomiting score was(1.16±0.40)points,which were lower than(1.58±0.43),(1.52±0.48),and(1.61±0.45)points in the control group(P<0.05).After treatment,CD3+and CD4+/CD8+in both groups were significantly higher than those before treatment;the study group had CD3+of(41.92±2.43)%and CD4+/CD8+of(1.89±0.34),which were higher than(38.05±2.18)%and(1.52±0.31)in the control group(P<0.05).After treatment,the physiological,psychological,environmental and social relationship scores in both groups were significantly higher than those before treatment;in the research group,the physiological score was(89.75±6.48)points,the psychological score was(89.07±6.02)points,the environmental score was(90.14±6.15)points and the social relation score was(89.96±6.27)points,which were higher than(82.93±6.85),(82.40±6.13),(83.27±6.30)and(83.14±6.54)points in the control group(P<0.05).Conclusion For patients with severe acute pancreatitis,early blood perfusion combined with ulinastatin treatment can enhance the patient's disease control effect,improve their symptoms,inflammatory response,immune function and quality of life.
Severe acute pancreatitisBlood perfusionEarly-stageUlinastatinEffect
万方数据
维普
