Analysis of cause of death and related influencing factors of 70 cases of late-pregnancy stillbirth
Objective To analyze the cause of death and related influencing factors of late-pregnancy stillbirth,so as to provide evidence for the development of effective preventive measures.Methods The death reports,relevant clinical data and anti-phospholipid antibody detection results of 70 cases of late-pregnancy stillbirth were retrospectively analyzed,and the causes of stillbirth and related influencing factors were analyzed.The incidence of late-pregnancy stillbirth in different types of pregnant women was compared,and the cause of late-pregnancy stillbirth and its correlation with anti-phospholipid antibody were analyzed.Results The incidence of stillbirth in pregnant women<20 years old was significantly higher than those 20-35 years old and>35 years old;the incidence of stillbirth in pregnant women in junior high school or below was significantly higher than those in senior high school or above;the incidence of stillbirth in pregnant women with multiple fetuses was significantly higher than those with single fetus;the incidence of stillbirth in pregnant women with pregnancy complications was significantly higher than those without;the incidence of stillbirth in pregnant women without regular obstetric checkups was significantly higher than those with regular checkups;the differences were all statistically significant(P<0.05).There was no significant difference in the incidence of stillbirth among pregnant women with different household registrations and delivery times(P>0.05).Among the 70 cases of stillbirth,10 cases(14.29%)had more than 2 causes of stillbirth,with a total of 84 cases/times.The top three classifications of causes of stillbirth were:fetal factors in 28 cases/times(33.33%),maternal factors in 24 cases/times(28.57%),and unknown diagnosis in 14 cases/times(16.67%).The top three specific causes of stillbirth were:fetal anomalies in 26 cases/times(30.95%);unknown diagnosis in 14 cases/times(16.67%);and umbilical cord torsion in 10 cases/times(11.90%).Of the 70 pregnant women who developed stillbirths,22 cases underwent antiphospholipid major antibody testing,and the positive rate of anti-phospholipid antibody was 45.45%(10/22);among them,the lupus anticoagulant test was positive in 52.63%(10/19);anticardiolipin antibody testing was performed in 22 cases,and the results were negative in all of them;and the positive rate of anti-β2 glycoprotein-1 antibody was 5.88%(1/17).1 pregnant women was positive for both lupus anticoagulant and anti-β2 glycoprotein-1 antibodies.Of the 10 lupus anticoagulant test-positive pregnant women,4 cases had intrahepatic cholestasis of pregnancy,with an incidence of 21.05%(4/19),and 1 of the 9 negative pregnant women had intrahepatic cholestasis of pregnancy,with an incidence of 5.26%(1/19).Of the 10 lupus anticoagulant test-positive pregnant women,3 cases had hypertension-related diseases,with an incidence of 15.79%(3/19);of the 9 lupus anticoagulant test-negative pregnant women,there were no hypertension-related diseases.1 pregnant woman with both lupus anticoagulant and anti-β2 glycoprotein-1 antibody positivity had umbilical cord torsion with root hyperextension.Conclusion Tertiary prevention of birth defects should be strengthened,focusing on the implementation of primary and secondary prevention,mainly including pregnancy health popularization,prenatal health examination before marriage,standardized delivery check-up,prenatal screening and prenatal diagnosis.The management of high-risk pregnant women should be strengthened,and attention should be paid to the screening and management of autoimmune diseases such as antiphospholipid antibody syndrome,so that early detection,diagnosis and treatment should be effectively done to reduce the incidence of late-pregnancy stillbirth.
Late pregnancyStillbirthCause of deathInfluencing factors
万方数据
维普
