Clinical efficacy of recombinant human brain natriuretic peptide combined with levosimendan in the treatment of refractory heart failure and its impact on cardiac function
Objective To explore the clinical efficacy of recombinant human brain natriuretic peptide combined with levosimendan in the treatment of refractory heart failure and its impact on cardiac function.Methods 80 patients with refractory heart failure were selected and randomly divided into a study group and a control group,with 40 patients in each group.The control group was treated with conventional methods,and the study group was treated with levosimendan on the basis of the control group.The clinical efficacy,endothelial function indicators[nitric oxide(NO),endothelin-1(ET-1)]before and after treatment and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the study group was 80.00%,which was significantly higher than 60.00%of the control group(P<0.05).Before treatment,there was no significant difference in NO and ET-1 between the two groups(P>0.05).After treatment,NO in both groups was higher than that before treatment,and ET-1 was lower than that before treatment;the study group had higher NO of(77.91±7.64)μmol/L than(68.35±6.42)μmol/L in the control group,and lower ET-1 of(38.29±4.71)ng/L than(44.19±5.37)ng/L in the control group;there was statistical difference(P<0.05).The incidence of adverse reactions was 12.50%in the study group and 10.00%in the control group.There was no significant difference between the two groups(P>0.05).Conclusion The combination of recombinant human brain natriuretic peptide and levosimendan demonstrates significant clinical efficacy and effectively improves cardiac function in patients with refractory heart failure,and the positive results after treatment provide new ideas for the management of refractory heart failure.However,further large-scale research is still needed to verify its long-term effectiveness and safety.The potential value of this treatment strategy provides beneficial insights for the rehabilitation and quality of life of heart failure patients.
Recombinant human brain natriuretic peptideLevosimendanRefractory heart failureClinical efficacyCardiac function
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