Effects of modified Yishen Tongluo Decoction on scores of traditional Chinese medicine syndrome,renal function,urinary microalbumin,podocalyxin and PAI-1 in patients with diabetic nephropathy
Objective To explore the effects of modified Yishen Tongluo Decoction on scores of traditional Chinese medicine syndrome,renal function,urinary microalbumin,podocalyxin and plasminogen activator inhibitor-1(PAI-1)in patients with diabetic nephropathy.Methods A total of 80 patients with diabetic nephropathy admitted to the hospital were were divided into Yishen Tongluo group and control group according to simple random method,with 40 cases in each group.The control group was treated with routine Western medicine,while the Yishen Tongluo group was additionally treated with modified Yishen Tongluo Decoction.Patients in both groups were compared in terms of incidence of adverse reactions,scores of traditional Chinese medicine syndrome,renal function indexes[serum creatinine(Scr),blood urea nitrogen(BUN)],urinary microalbumin,podocalyxin,and PAI-1.Results Compared with before treatment,the scores of turbid urine,shortness of breath and laziness to speak,lumbago,dizziness and dreaminess,frequency of urination and polyuria,feverishness in palms and soles in the two groups were all reduced after treatment,and the difference was statistically significant(P<0.05).After treatment,the scores of turbid urine,shortness of breath and laziness to speak,lumbago,dizziness and dreaminess,frequency of urination and polyuria,feverishness in palms and soles in the Yishen Tongluo group were lower than those of the control group,and the difference was statistically significant(P<0.05).Before treatment,the levels of Scr and BUN levels of patients in the Yishen Tongluo group were(213.63±8.61)μmol/L and(20.96±2.64)mmol/L,while those in the control group were(214.21±8.49)μmol/L and(21.16±2.41)mmol/L.After treatment,the levels of Scr and BUN levels in the Yishen Tongluo group were(88.61±5.45)μmol/L and(11.36±2.64)mmol/L,while those in the control group were(98.64±5.14)μmol/L and(15.64±2.68)mmol/L.Compared with before treatment,the levels of Scr and BUN in both groups of patients decreased after treatment,and the difference was statistically significant(P<0.05).After treatment,the levels of Scr and BUN in the Yishen Tongluo group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,the levels of podocalyxin,PAI-1,and urinary microalbumin in the Yishen Tongluo group were(13.63±3.61)ng/ml,(30.96±2.64)ng/ml,and(92.16±10.48)mg/24 h,while those in the control group were(14.21±3.49)ng/ml,(31.16±2.41)ng/ml,and(92.39±10.31)mg/24 h.After treatment,the levels of podocalyxin,PAI-1,and urinary microalbumin in the Yishen Tongluo group were(8.61±1.45)ng/ml,(21.36±2.64)ng/ml,and(51.43±10.41)mg/24 h,while those in the control group were(10.64±1.14)ng/ml,(25.64±2.68)ng/ml,and(72.04±10.69)mg/24 h.Compared with before treatment,the levels of urinary microalbumin,podocalyxin,and PAI-1 in both groups of patients decreased after treatment,and the difference was statistically significant(P<0.05).After treatment,the levels of urinary microalbumin,podocalyxin,and PAI-1 in the Yishen Tongluo group were lower than those in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in both groups was 2.5%(1/40),and there was no statistically significant difference between the groups(P>0.05).Conclusion Modified Yishen Tongluo Decoction can improve traditional Chinese medicine syndrome and promote the recovery of renal function in patients with diabetic nephropathy.
Modified Yishen Tongluo DecoctionDiabetic nephropathyScores of traditional Chinese medicine syndromeRenal functionPodocalyxinUrinary microalbumin
万方数据
维普
