Observation on the effect of modified Bushen Huoxue Xiaozheng Decoction combined with GnRH-a in the treatment of endometriosis (cold-coagulation and blood-stasis syndrome)
Objective To observe the clinical effect of modified Bushen Huoxue Xiaozheng Decoction combined with gonadotropin-releasing hormone agonists (GnRH-a) in the treatment of endometriosis (EMT,cold-coagulation and blood-stasis syndrome). Methods 90 patients with EMT (cold-coagulation and blood-stasis syndrome) were selected and divided into a control group and an observation group according to their admission order,with 45 cases in each group. The control group was treated with GnRH-a,and the observation group was treated with modified Bushen Huoxue Xiaozheng Decoction on the basis of the control group. The therapeutic effect,traditional Chinese medicine syndrome score,sex hormone level and the occurrence of adverse reactions were compared between the two groups. Results The total effective rate of 95.56％ in the observation group was higher than 82.22％ in the control group (P<0.05). After 6 months of treatment,the traditional Chinese medicine syndrome scores for main symptom and minor symptom in both groups were lower than those before treatment;the traditional Chinese medicine syndrome scores for main symptom and minor symptom were (1.42±0.27) and (1.76±0.33) points in the observation group,which were lower than (1.96±0.42) and (2.25±0.47) points in the control group (P<0.05). After 6 months of treatment,the estradiol (E2),luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in both groups were better than those before treatment;the E2 level of (71.39±7.85) pmol/L in the observation group was higher than (54.16±5.71) pmol/L in the control group;the levels of LH and FSH were (2.31±0.76) and (11.72±1.24) IU/L in the observation group,which were lower than (4.19±1.02) and (16.78±1.95) IU/L in the control group (P<0.05). The incidence of adverse reactions of 4.44％ in the observation group was lower than 20.00％ in the control group (P<0.05). Conclusion The application of modified Bushen Huoxue Xiaozheng Decoction combined with GnRH-a has a definite effect on patients with EMT (cold-coagulation and blood-stasis syndrome),which can improve the clinical efficacy,improve the patients' traditional Chinese medicine syndromes and the level of sex hormones,and protect the patients' subsequent fertility,and also reduce the adverse reactions,which is worthy of application.
Bushen Huoxue Xiaozheng DecoctionGonadotropin-releasing hormone agonistsEndometriosisCold-coagulation and blood-stasis syndrome
万方数据
维普
