Effect of left stellate ganglion block on hemodynamics and prognosis in patients undergoing open heart surgery
Objective To explore the effect of left stellate ganglion block on hemodynamics and prognosis in patients undergoing open heart surgery. Methods 111 patients who underwent open heart surgery were selected as the research subjects. According to the random number distribution method,they were divided into an observation group (56 cases) and a control group (55 cases). In the control group,the blood samples in the right neck of the patients were collected after local anesthesia,then underwent open heart surgery. The observation group underwent left stellate ganglion block based on the control group. Comparison was made on hemodynamic indicators,plasma inflammatory factors[tumor necrosis factor-α (TNF-α),interleukin-8 (IL-8),interleukin-10 (IL-10)],plasma levels of nerve tissue protein (S100β) and neuron specific enolase (NSE) after retrograde catheterization (T0),10 min after aortic opening (T1),2 h after surgery (T2),6 h after surgery (T3),and 24 after surgery between the two groups. Results There was no significant difference in mean arterial pressure (MAP) and heart rate (HR) between the two groups at T0-T4 (P>0.05). There was no significant difference in plasma levels of inflammatory factors at T0 between the two groups (P>0.05). TNF-α,IL-8 and IL-10 at T1-T4 in both groups at T1-T4 were higher than those at T0,and TNF-α,IL-8 and IL-10 in the observation group were better than those in the control group at T1-T4 (P<0.05). TNF-α,IL-8 and IL-10 in both groups increased first and then decreased with time at T1-T4,and reached the highest level at T2. At T0-T4,in the observation group,S100β were (0.33±0.10),(1.26±0.25),(1.02±0.04),(0.67±0.15) and (0.43±0.11) μg/L,and NSE were (7.68±0.59),(10.09±0.78),(9.41±0.62),(9.10±0.66) and (8.01±0.51) μg/L;in the control group,S100β were (0.31±0.08),(1.52±0.35),(1.18±0.12),(1.05±0.33) and (0.52±0.25) μg/L,and NSE were (7.56±0.65),(11.35±1.33),(10.66±1.01),(10.56±1.01) and (8.98±0.68) μg/L. Compared with T0,the levels of S100β and NSE increased at T1-T4 in both groups (P<0.05). Compared with the control group,S100β and NSE level of patients in the observation group were decreased at T1-T4 (P<0.05). Conclusion Left stellate ganglion block has little effect on hemodynamics,but it can reduce the inflammatory reaction in patients,and improve nerve factors.
Left stellate ganglion blockOpen heart surgeryHemodynamicsInflammatory factors
万方数据
维普
