Study on drug resistance of multi-drug resistant bacteria in patients with pulmonary infection
Objective To investigate the drug resistance of multi-drug resistant bacteria (MDR) in patients with pulmonary infection. Methods 50 patients with pulmonary infection were selected to undergo pathogen culture and drug susceptibility test. The composition of multi-drug resistant bacteria,drug resistance of gram-negative bacteria and drug resistance of gram-positive bacteria in pulmonary infection were analyzed. Results A total of 255 stains of pathogenic bacteria were isolated from the sputum samples of 50 patients with pulmonary infection,of which 95 strains (37.3％) were identified as multi-drug resistant bacteria. There were 75 strains (78.9％) of Gram-negative bacteria and 20 strains (21.1％) of Gram-positive bacteria in multi-drug resistant bacteria. The drug resistance rate of 19 strains of Pseudomonas aeruginosa to piperacillin,ceftazidme,cefepime,aztreonam and ciprofloxacin was>63％. The drug resistance rate of 16 strains of Klebsiella pneumoniae to ampicillin/sulbactam,cefazolin,ceftazidme,cefuroxime and ceftriaxone was more than 56％. The drug resistance rate of 14 strains of Acinetobacter baui to ampicillin,ampicillin/sulbactam,cefepime and amikacin was ≥50％. The drug resistance rate of 11 E. coli strains to ampicillin/sulbactam,cefazolin,ceftazidme,cefuroxime,ceftriaxone,aztreonam,levofloxacin and cotrimoxazole was>54％. The drug resistance rate of 7 strains of stenotrophomonas maltophilia to cefazolin and levofloxacin was>57％. The drug resistance rate of 7 strains of Staphylococcus aureus to cefoxitin,penicillin,erythromycin,clindamycin,and gentamicin was>57.0％. The drug resistance rate of 4 strains of Staphylococcus epidermidis to cefoxitin,penicillin,erythromycin,clindamycin,gentamicin and cotrimoxazole was ≥75％. The drug resistance rate of 4 strains of Streptococcus pneumoniae to erythromycin and clindamycin was 100％. Conclusion Multi-drug resistant bacteria has been found in sputum samples of patients with pulmonary infection,and analysis of the resistance of different bacteria to different antibiotics can provide an important reference for the subsequent control of pulmonary infection.
Pulmonary infectionMulti-drug resistant bacteriaDrug resistanceGram-negative bacteriaGram-positive bacteriaDrug sensitivity test
万方数据
维普
