Effect of anesthesia with remifentanil and propofol on hemodynamics and cognitive function in patients undergoing laparoscopic cholecystectomy
Objective To explore the effect of anesthesia with remifentanil and propofol on hemodynamics and cognitive function in patients undergoing laparoscopic cholecystectomy. Methods A total of 42 patients undergoing laparoscopic cholecystectomy were divided into a control group and an observation group based on the random number table method,each consisting of 21 patients. The control group received anesthesia with fentanyl and propofol,while the observation group received anesthesia with remifentanil and propofol. Patients in both groups were compared in terms of recovery status after anesthesia,hemodynamics[mean arterial pressure (MAP),heart rate (HR),diastolic blood pressure (DBP),systolic blood pressure (SBP)],cognitive function[observer's assessment of the alertness/sedation scale (OAAS),Mini-Mental State Examination (MMSE)]and complications. Results The extubation time,recovery time,recovery time of spontaneous respiration and recovery time of directional force were (9.87±1.75),(8.12±0.94),(5.24±1.11) and (15.43±2.82) min in the observation group,which were shorter than (13.23±1.86),(10.36±1.23),(7.35±1.42) and (21.64±3.46) min in the control group,and the difference was statistically significant (P<0.05). In the control group,the levels of HR,DBP and SBP at 0.5 h after anesthesia were lower than those at 0.5 h before anesthesia in this group,and the level of MAP was higher than that at 0.5 h before anesthesia in this group,and the differences were statistically significant (P<0.05). In the observation group,the levels of HR,DBP,SBP and MAP at 0.5 h after anesthesia were not statistically significant when compared with those at 0.5 h before anesthesia (P>0.05). However,the observation group had HR of (95.76±2.26) beats/min,DBP of (75.58±3.47) mm Hg (1 mm Hg=0.133 kPa),and SBP of (134.33±4.85) mm Hg,which were higher than (89.32±2.48) beats/min,(72.19±3.54) mm Hg,and (113.77±4.45) mm Hg in the control group;and MAP of (67.67±5.28) mm Hg in the observation group was lower than (71.53±5.64) mm Hg in the control group;the differences were statistically significant (P<0.05). The OAAS scores of the control group and the observation group at 24 h after extubation were (4.22±0.62) and (4.33±0.65) points,which were higher than (3.23±0.56) and (3.24±0.57) points in this group at the time of extubation,and the differences were statistically significant (P<0.05),but the differences were not statistically significant when comparing between the two groups (P>0.05). The MMSE scores in both groups at 24 h after extubation were higher than those at the time of extubation in this group,and the MMSE score of (28.47±1.13) points in the observation group was higher than (26.54±1.76) points in the control group. The differences were not statistically significant (P<0.05). Comparison of complication rates between the two groups was not statistically significant (P>0.05). Conclusion Anesthesia with remifentanil and propofol can effectively stabilize the hemodynamics of patients undergoing laparoscopic cholecystectomy and promote the recovery of body and cognitive function after anesthesia.
万方数据
维普
