Efficacy analysis of intraocular injection of leizumab combined with fundus laser in the treatment of macular edema secondary to branch retinal vein occlusion
Objective To explore the clinical effect of intraocular injection of leizumab combined with fundus laser in the treatment of macular edema (ME) secondary to branch retinal vein occlusion (BRVO). Methods A total of 88 patients with ME secondary to BRVO were selected as the subjects of this study and divided into a study group and a control group according to the envelope method,with 44 cases in each group. The study group received intraocular injection of leizumab and fundus laser combined treatment,while the control group was treated with fundus laser. The best corrected visual acuity,macular fovea thickness,occurrence of adverse reactions were compared between the two groups. Results Before treatment,there was no statistical significance in the best corrected visual acuity and the macular fovea thickness between the two groups (P>0.05). After 6 months of treatment,the best corrected visual acuity and the macular fovea thickness in both groups were less than those before treatment;the study group had best corrected visual acuity of (0.30±0.08) and macular fovea thickness of (288.98±24.39) μm,which were lower than (0.39±0.10) and (347.86±35.27) μm in the control group (P<0.05). There was no statistical significance in the incidence of transient intraocular elevation,vitreous hemorrhage,bulbar conjunctival hemorrhage and endophthalmitis between the two groups (P>0.05). Conclusion The combination of intraocular injection of leizumab and fundus laser is effective and safe in the treatment of ME secondary to BRVO,and can effectively improve the best corrected visual acuity and the macular fovea thickness of patients.
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