首页|糜蛋白酶在化脓性伤口治疗中的临床应用效果分析

糜蛋白酶在化脓性伤口治疗中的临床应用效果分析

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目的 探讨糜蛋白酶在化脓性伤口治疗中的临床应用效果.方法 选取180例伤口化脓感染患者,按照换药方式不同分为观察组和对照组,每组90例.对照组采用常规方法换药后使用生理盐水浸湿无菌纱布湿敷患处;观察组在常规方法换药后使用糜蛋白酶浸湿无菌纱布湿敷患处.比较两组患者伤口愈合时间、换药次数、换药总费用及伤口疼痛程度.结果 观察组伤口愈合时间(15.0±3.8)d短于对照组的(23.0±5.9)d,换药次数(10±2)次少于对照组的(14±3)次,换药总费用(515.8±165.5)元少于对照组的(825.6±205.3)元(P<0.05).治疗后,两组患者视觉模拟评分法(VAS)评分均低于治疗前,且观察组VAS评分(2.32±1.34)分低于对照组的(3.50±1.25)分(P<0.05).结论 糜蛋白酶在化脓性伤口治疗中具有较好临床效果,有助于促进切口愈合,减少换药次数,减轻患者经济负担及痛苦,值得临床推广.
Analysis of the clinical effect of chymotrypsin in the treatment of suppurative wounds
Objective To explore the clinical effect of chymotrypsin in the treatment of suppurative wounds. Methods 180 patients with suppurative wounds were selected,and were divided into an observation group and a control group according to the different dressing change methods,with 90 patients in each group. In the control group,after the routine dressing change,the saline-soaked sterile gauze was applied for wet compress of the wounds. As for the observation group,after the routine dressing change,chymotrypsin-soaked sterile gauze was applied for wet compress of the wounds. The wound healing time,frequency of dressing changes,total cost of dressing change,and degree of wound pain were compared between the two groups. Results The observation group had shorter wound healing time of (15.0±3.8) d than (23.0±5.9) d in the control group,less frequency of dressing changes of (10±2) times than (14±3) times in the control group,and less total cost of dressing changes of (515.8±165.5) yuan than (825.6±205.3) yuan in the control group (P<0.05). After treatment,the visual analogue scale (VAS) score in both groups was lower than that before treatment,and the VAS score of (2.32±1.34) points in the observation group was lower than (3.50±1.25) points in the control group (P<0.05). Conclusion Chymotrypsin has shown a satisfactory clinical effect in treating suppurative wounds and helps to promote incision healing,reduce the frequency of dressing changes,lessen the financial burden and relieve the pain of patients,so it is worthy of a promoted clinical application.

ChymotrypsinSuppurative woundsBacterial biofilmWound dressingWet compress

杨文光、李超

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737100 甘肃省金昌市人民医院

710200 西安市公共卫生中心(西安市应急医疗中心)

糜蛋白酶 化脓性伤口 细菌生物膜 伤口换药 湿敷

2024

中国实用医药
中国康复医学会

中国实用医药

影响因子:0.797
ISSN:1673-7555
年,卷(期):2024.19(21)