Effect of massive blood transfusion on coagulation function in patients with severe trauma
Objective To analyze the effect of massive blood transfusion on coagulation function in patients with severe trauma. Methods 140 cases of severe trauma patients were divided into an observation group and a control group according to the amount of blood transfusion,with 70 cases in each group. The observation group was treated with massive blood transfusion,and the control group was treated with less blood transfusion. Patients in both groups were compared in terms of coagulation function indexes[platelet count (PLT),thrombin time (TT),activated partial thromboplastin time (APTT),prothrombin time (PT),fibrinogen (FIB)]and inflammatory factors[interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),C-reactive protein (CRP)]before and after treatment. Results After treatment,the observation group had PLT of (129.55±7.50)×109/L and FIB of (1.31±0.48) g/L,which were lower than (180.15±7.63)×109/L and (2.20±0.55) g/L in the control group;the observation group had TT of (21.23±2.99) s,APTT of (39.88±7.55) s,and PT of (15.95±1.77) s,which were longer than (19.20±2.80),(34.27±5.45),and (12.88±1.90) s in the control group;the difference was statistically significant (P<0.05). After treatment,the observation group had IL-6 of (114.20±12.21) ng/L,TNF-α of (1.85±0.35) ng/ml and CRP of (29.58±4.01) mg/L,which were higher than (99.60±9.30) ng/L,(1.40±0.30) ng/ml and (21.27±3.45) mg/L in the control group,and the difference was statistically significant (P<0.05). Conclusion Massive blood transfusion has a great impact on the coagulation function of patients with severe trauma,and the corresponding prevention of coagulation dysfunction and inflammatory reaction should be done,and the vital signs of patients should be carefully observed to ensure the effect of blood transfusion.
Severe traumaMassive blood transfusionBlood coagulation function
万方数据
维普
