Clinical effect of Reke teabag combined with acupoint application on mycoplasma pneumoniae pneumonia in children(accumulation of phlegm-heat syndrome)and its influence on serum inflammatory factors and immune function
Objective To explore the effect of Reke teabag combined with acupoint application on mycoplasma pneumoniae pneumonia(MPP)in children(accumulation of phlegm-heat syndrome)and its influence on serum inflammatory factors and immune function.Methods A total of 80 children patients with MPP(accumulation of phlegm-heat syndrome)were randomly divided into an observation group and a control group,each consisting of 40 patients.The control group was treated with azithromycin for suspension,and the observation group was treated with Reke teabag and acupoint application on the basis of the control group.Comparison was made on therapeutic effect,symptom disappearance time(disappearance time of fever,disappearance time of cough,disappearance time of lung rales),traditional Chinese medicine syndrome score,serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),serum amyloid A(SAA)],complement 3(C3),complement 4(C4)and immunoglobulin[immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)],and occurrence of adverse reactions.Results The total effective rate of 97.5%in the observation group was significantly higher than 82.5%in the control group,and the difference was statistically significant(P<0.05).In the observation group,the disappearance time of fever was(1.17±0.31)d,the disappearance time of cough was(3.50±0.55)d,and the disappearance time of lung rales was(3.77±0.42)d,which were shorter than(2.48±0.49),(4.33±0.70),and(5.07±0.36)d in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of fever,cough,shortness of breath and gurgling with sputum and total score in both groups were lower than those before treatment,and the observation group was significantly lower than the control group.The difference was statistically significant(P<0.05).After treatment,TNF-α,IL-6,IL-10,and SAA in both groups were significantly lower than those before treatment;the observation group had TNF-α of(15.66±1.57)ng/L,IL-6 of(17.30±3.04)ng/L,IL-10 of(18.91±1.30)ng/L,and SAA of(30.69±7.78)mg/L,which were significantly lower than(17.89±1.81)ng/L,(24.34±2.88)ng/L,(23.96±1.07)ng/L,and(37.30±7.15)mg/L in the control group(P<0.05).After treatment,IgA and IgG were increased in both groups,and IgM,C3 and C4 were decreased;the observation group had IgA of(0.84±0.09)g/L and IgG of(8.27±1.30)g/L,which were significantly higher than(0.74±0.10)and(7.11±1.30)g/L in the control group;the observation group had IgM of(1.03±0.10)g/L,C3 of(0.84±0.24)g/L and C4 of(0.23±0.11)g/L,which were significantly lower than(1.28±0.11),(1.16±0.26),and(0.30±0.13)g/L in the control group(P<0.05).The incidence rate of adverse reactions in both groups was 2.5%,and there was no significant difference in the comparison between the two groups(P>0.05),and there was no special discomfort and no need for special treatment.Conclusion Reke teabag combined with acupoint application shows significant clinical efficacy in treating MPP.It can improve the clinical symptoms and pulmonary signs,reduce traditional Chinese medicine syndrome score,effectively reduce inflammation,increase the level of immunoglobulin,recovery C3 and C4,improve the immune function of children with high safety.
Reke teabagAcupoint applicationMycoplasma pneumoniae pneumoniaChildrenAccumulation of phlegm-heat syndromeInflammatory factorsImmune
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