Study on the effect of remazolam benzenesulfonate combined with remifentanil anesthesia under the guidance of target entropy index in patients undergoing painless fiberoptic bronchoscopy with laryngeal mask ventilation
Objective To investigate the application effect of remazolam benzenesulfonate combined with remifentanil anesthesia under the guidance of target entropy index in patients undergoing painless fiberoptic bronchoscopy with laryngeal mask ventilation.Methods A total of 80 elderly patients who received painless fiberoptic bronchoscopy under laryngeal mask ventilation were selected and divided into an observation group(40 cases)and a control group(40 cases)by random numerical table.The observation group was given remazolam benzenesulfonate combined with remifentanil anesthesia under the guidance of target entropy index,and the control group was given propofol combined with remifentanil anesthesia under the guidance of target entropy index.Both groups were compared in terms of success rate of sedation,examination time and recovery time,hemodynamic and respiratory function-related indexes[mean arterial pressure(MAP),heart rate(HR),pulse oxygen saturation(SpO2),respiratory rate(RR),and state entropy(SE)]at different time points[before anesthesia(i.e.,5 min after calm oxygen inhalation,T0),immediately after anesthesia induction(T1),immediately after endoscopic entry into the vocal folds(T2),immediately after arrival of the endoscope at the ronchi(T3),during the examination(i.e.,10 min after anesthesia induction,T4),immediately after the examination(T5),and immediately after exit from the room(T6)],as well as the occurrence of intraoperative adverse events and postoperative adverse reactions.Results There was no significant difference in the success rate of sedation,examination time and recovery time between the two groups(P>0.05).MAP and SE at T1,T2,T3,T4,T5 and T6 in both groups were lower than those at T0(P<0.05).MAP of the observation group were(96.96±6.90),(96.18±7.03),(96.33±7.52)and(94.35±6.32)mm Hg(1 mm Hg=0.133 kPa)at T3,T4,T5 and T6,which were higher than(93.13±7.47),(92.44±7.72),(92.79±8.03)and(91.10±7.54)mm Hg of the control group(P<0.05).The incidence of adverse events of 5.00%in the observation group was lower than 20.00%in the control group(P<0.05).There was no significant difference in the incidence of postoperative adverse reactions between the two groups(P>0.05).Conclusion Remazolam benzenesulfonate combined with remifentanil anesthesia under the guidance of target entropy index is more effective for induction and intraoperative maintenance of general anesthesia for elderly patients undergoing painless fiberoptic bronchoscopy with laryngeal mask ventilation,with a high success rate of sedation,less influence on hemodynamics and respiratory function during operation,and fewer complications.
Painless fiberoptic bronchoscopyLaryngeal mask ventilationRemazolam benzenesulfonateRemifentanilTarget entropy indexAnesthesiaOld age
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