Clinical value of NT-proBNP,D-dimer and NLR combined detection in the diagnosis of acute pulmonary embolism
Objective To study the clinical value of N-terminal pro-brain natriuretic peptide(NT-proBNP),D-dimer(D-D)and neutrophils to lymphocyte ratio(NLR)combined detection in the diagnosis of acute pulmonary embolism.Methods A total of 60 patients with acute pulmonary embolism were selected as the pulmonary embolism group,including 30 patients with medium-risk pulmonary embolism and 30 patients with low-risk pulmonary embolism,and 60 healthy subjects were selected as the control group.Within 24 h after admission,5 ml of venous blood was collected from all subjects to detect the levels of NT-proBNP,D-D and NLR.The levels of NT-proBNP,D-D,and NLR were compared between the pulmonary embolism group and the control group,and between patients with medium-risk pulmonary embolism and patients with low-risk pulmonary embolism in the pulmonary embolism group,and the diagnostic sensitivity and specificity of the combined detection of NT-proBNP,D-D,and NLR for acute pulmonary embolism were analyzed.Results The pulmonary embolism group had NT-proBNP of(412.68±181.29)pg/ml,D-D of(8.78±1.75)mg/L and NLR of(5.60±0.35),which were significantly higher than(84.30±9.21)pg/ml,(0.24±0.02)mg/L and(1.33±0.21)in the control group,and there was significant difference(P<0.05).In patients with medium-risk pulmonary embolism,NT-proBNP was(613.22±231.49)pg/ml,D-D was(9.65±0.64)mg/L,and NLR was(6.86±0.96),which were significantly higher than(212.13±119.46)pg/ml,(7.91±0.91)mg/L,and(4.33±0.31)in patients with low-risk pulmonary embolism,and there was significant difference(P<0.05).The sensitivity of the combined detection of NT-proBNP,D-D,and NLR for acute pulmonary embolism was 93.3%,which was higher than 68.3%of NT-proBNP and 73.3%of NLR,and there was significant difference(P<0.05);the specificity of the combined detection was 61.7%,which had no significant difference compared with 61.7%of D-D,66.7%of NT-proBNP and 65.0%of NLR(P>0.05).Conclusion Combined detection of NT-proBNP,D-D and NLR for patients with acute pulmonary embolism can judge the risk level early,which is of important clinical guidance.
N-terminal pro-brain natriuretic peptideD-dimerNeutrophils to lymphocyte ratioAcute pulmonary embolismDiagnostic value
NETL
NSTL
万方数据
