Analysis of the effect of clopidogrel resistance on the prognosis of elderly patients with acute coronary syndrome undergoing percutaneous coronary intervention
Objective To analyze the effect of clopidogrel resistance on the prognosis of elderly patients with acute coronary syndrome(ACS)undergoing percutaneous coronary intervention.Methods 100 elderly patients with acute coronary syndrome were selected as the study subjects.Both groups were treated with percutaneous coronary intervention and clopidogrel and aspirin before and after surgery.Based on the decrease in platelet aggregation rate before and after treatment,the patients were divided into a clopidogrel resistance group(observation group)and a non clopidogrel resistance group(control group),with 50 patients in each group.The occurrence of adverse events,platelet activity indices,inflammatory factor level and re-hospitalization were compared between the two groups.Results The incidence of adverse events of 26.00%in the observation group was higher than 10.00%in the control group(P<0.05).After treatment,the observation group had thromboxane B2(TXB2)of(61.51±7.47)ng/L,granule membrane protein-140(GMP-140)of(11.28±2.51)%and procaspase-activating compound 1(PAC-1)of(8.32±2.57)%,which were lower than(65.33±9.21)ng/L,(12.31±2.14)%and(9.41±2.12)%in the control group.The difference between groups was statistically significant(t=2.278,2.208,2.313;P<0.05).After treatment,the observation group had interleukin-6(IL-6)of(8.61±4.18)ng/L,interleukin-8(IL-8)of(134.49±42.73)ng/L,hypersensitive C-reactive protein(hs-CRP)of(2.24±1.76)mg/L,and tumor necrosis factor-α(TNF-α)of(4.86±2.34)ng/L,which were lower than(11.35±4.24)ng/L,(169.25±51.46)ng/L,(4.24±2.49)mg/L,and(7.36±3.54)ng/L in the control group.The difference between the two groups was statistically significant(t=3.254,3.675,4.638,4.166;P<0.05).The re-hospitalization rate of 38.0%in the observation group was higher than 18.0%in the control group,and the difference between the two groups was statistically significant(χ2=4.960,P=0.026<0.05).Conclusion Patients with acute coronary syndrome experience resistance to clopidogrel after percutaneous coronary intervention,which to some extent promotes the occurrence of cardiovascular adverse events,effectively inhibits platelet activity and inflammatory reactions,thus promoting the stability of the patient's condition.
NETL
NSTL
万方数据
