摘要
目的 观察普罗帕酮与胺碘酮治疗混合性心律失常的临床疗效.方法 272例混合性心律失常患者,根据随机数字表法分为对照组与观察组,每组 136 例.对照组实施胺碘酮治疗,观察组实施普罗帕酮+胺碘酮治疗.对比两组的临床疗效、心功能指标[左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)、心输出量(CO)、6 min步行距离]、血清炎症因子[白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)]水平、不良反应发生情况.结果 观察组治疗总有效率为95.59%,明显高于对照组的 82.35%(P<0.05).治疗后,观察组LVEDD(56.82±6.12)mm、LVESD(43.36±5.60)mm均明显小于对照组的(61.25±6.33)、(48.22±5.47)mm,LVEF(55.14±5.47)%、CO(4.75±0.48)L/min均明显高于对照组的(50.02±5.33)%、(4.10±0.45)L/min,6 min步行距离(530.11±38.59)m明显长于对照组的(422.96±31.56)m(P<0.05).治疗后,观察组hs-CRP、IL-6 水平分别为(8.15±2.16)mg/L、(18.96±1.96)pg/ml,均明显低于对照组的(12.23±3.25)mg/L、(23.10±2.03)pg/ml(P<0.05).两组不良反应发生率对比无明显差异(P>0.05).结论 对于混合性心律失常患者而言,普罗帕酮联合胺碘酮的临床疗效显著,利于心功能的改善及缓解炎性反应,值得临床采纳并推广.
Abstract
Objective To observe the clinical efficacy of propafenone and amiodarone in the treatment of mixed arrhythmias.Methods A total of 272 patients with mixed arrhythmia were divided into a control group and an observation group according to random numerical table,with 136 cases in each group.The control group was treated with amiodarone,and the observation group was treated with propafenone+amiodarone.Both groups were compared in terms of clinical efficacy,cardiac function indicators[left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF),cardiac output(CO),6-min walking distance],serum inflammatory factors[interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP)],and occurrence of adverse reactions.Results The total effective rate of the observation group was 95.59%,which was significantly higher than 82.35%of the control group(P<0.05).After treatment,the observation group had LVEDD of(56.82±6.12)mm and LVESD of(43.36±5.60)mm,which were significantly lower than(61.25±6.33)and(48.22±5.47)mm in the control group;the observation group had LVEF of(55.14±5.47)%and CO of(4.75±0.48)L/min,which were significantly higher than(50.02±5.33)%and(4.10±0.45)L/min in the control group;the 6-min walking distance of(530.11±38.59)m in the observation group was significantly longer than(422.96±31.56)m in the control group(P<0.05).After treatment,the levels of hs-CRP and IL-6 in the observation group were(8.15±2.16)mg/L and(18.96±1.96)pg/ml,which were significantly lower than(12.23±3.25)mg/L and(23.10±2.03)pg/ml in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion For patients with mixed arrhythmias,the clinical efficacy of propafenone combined with amiodarone is remarkable,which facilitates the improvement of cardiac function and alleviates the inflammatory response,and is worthy of clinical adoption and promotion.
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