Analysis of the application effect of nucleoside drugs in the treatment of post-hepatitis B cirrhosis
Objective To evaluate the application effect of nucleoside drugs in the treatment of post-hepatitis B cirrhosis.Methods 78 patients with post-hepatitis B cirrhosis were selected,and were divided into the experimental group(39 cases,nucleoside drug entecavir)and the control group(39 cases,adefovir)by drawing lots.The negative conversion rate,adverse reactions,alanine aminotransferase and viral load before and after treatment were compared between the two groups.Results The negative conversion rate of 89.74%in the experimental group was higher than 64.10%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no differences in alanine transaminase and viral load between the two groups(P>0.05).After treatment,the alanine transaminase and viral load of the experimental group were(54.66±1.22)U/L and(2.33±0.56)log10 copies/ml,which were lower than(71.22±2.45)U/L and(5.66±1.11)log10 copies/ml of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of 2.56%in the experimental group was lower than 17.95%in the control group,and the difference was statistically significant(P<0.05).Conclusion During the treatment of post-hepatitis B cirrhosis,the application of nucleoside drugs can not only improve the negative conversion rate of patients,but also reduce the incidence of adverse reactions and improve various indicators,which has a certain promotion value.Attention should be paid to the application of nucleoside drugs during the treatment of post-hepatitis cirrhosis.
Hepatitis BLiver cirrhosisNucleoside drugsNegative conversion rate
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