Study on clinical efficacy of magnesium aluminum carbonate combined with esomeprazole in the treatment of patients with gastric ulcer accompanied by bleeding
Objective To explore the clinical efficacy of magnesium aluminum carbonate combined with esomeprazole in the treatment of patients with gastric ulcer accompanied by bleeding.Methods A total of 82 patients with gastric ulcer accompanied by bleeding were selected and divided into a control group and a study group by random number table method,each with 41 cases.The control group was treated with esomeprazole,and the study group was treated with magnesium aluminum carbonate combined with esomeprazole.The clinical efficacy,gastrointestinal hormone and levels[serum gastrin(GAS),motilin(MTL)and cholecystokinin(CCK)]and adverse reactions of the two groups were compared.Results The total clinical effective rate of 95.1%in the study group was higher than 78.0%in the control group(P<0.05).After treatment,the study group had GAS of(72.7±8.4)ng/L and CCK of(12.8±2.4)μmol/L,which were lower than(81.2±9.1)ng/L and(15.2±2.5)μmol/L in the control group;MTL of(236.9±26.7)ng/L in the study group was higher than(215.3±20.7)ng/L in the control group(P<0.05).The incidence of adverse reactions 12.2%in the study group was lower than 31.7%in the control group(P<0.05).Conclusion The combination of magnesium aluminum carbonate and esomeprazole in the treatment of gastric ulcer accompanied by bleeding can achieve an ideal effect,it has high safety and is worthy of promotion.
Magnesium aluminum carbonateEsomeprazoleGastric ulcer accompanied by bleedingGastrointestinal hormoneClinical efficacyAdverse reactions
NETL
NSTL
万方数据
