Impact of modified Liyuan Decoction combined with quadruple therapy on the therapeutic effect and gastric mucosal injury of patients with chronic gastritis of spleen deficiency and stomach dryness type
Objective To analyze the impact of modified Liyuan Decoction combined with quadruple therapy on the therapeutic effect and gastric mucosal injury of patients with chronic gastritis(CG)of spleen deficiency and stomach dryness type.Methods 120 patients with CG of spleen deficiency and stomach dryness type as study subjects were randomly divided into an observation group(modified Liyuan Decoction+quadruple therapy)and a control group(quadruple therapy),each with 60 cases.The gastric mucosal injury,inflammatory factor level,traditional Chinese medicine syndrome score,treatment effect and quality of life were compared between the two groups.Results After treatment,the ratio of pepsinogen Ⅰ to pepsinogen Ⅱ(PGR)of the observation group was(7.1±0.9)and the pepsinogenⅠ(PGⅠ)was(60.0±11.6)μg/L,which were higher than(5.0±0.8)and(49.6±10.3)μg/L of the control group;the pepsinogen Ⅱ(PGⅡ)of(8.0±2.6)μg/L of the observation group was lower than(10.1±2.1)μg/L of the control group(P<0.05).After treatment,the observation group had interleukin-8 of(9.2±0.1)μg/L,tumor necrosis factor-α of(2.9±0.1)ng/L,interleukin-6 of(17.2±2.2)ng/L,and hypersensitive C-reactive protein of(2.1±0.1)mg/L;the control group had interleukin-8 of(10.5±0.1)μg/L,tumor necrosis factor-α of(3.4±0.2)ng/L,interleukin-6 of(28.8±3.5)ng/L,and hypersensitive C-reactive protein of(3.8±0.1)mg/L.The hypersensitive C-reactive protein,interleukin-6,interleukin-8,and tumor necrosis factor-α of the observation group were significantly lower than those of the control group(P<0.05).After treatment,the epigastric fullness score of the observation group was(0.2±0.1)points,the stomachache score was(0.3±0.1)points,the acid reflux score was(0.2±0.1)points,the lethargy score was(0.2±0.1)points,and the indigestion and loss of appetite score was(0.2±0.1)points;the epigastric fullness score of the control group was(0.6±0.2)points,the stomachache score was(0.8±0.3)points,the acid reflux score was(0.7±0.3)points,the lethargy score was(0.7±0.1)points,and the indigestion and loss of appetite score was(0.8±0.2)points.The scores of epigastric fullness,stomachache,acid reflux,lethargy,and indigestion and loss of appetite in the observation group were significantly lower than those in the control group(P<0.05).The total effective rate of 96.7%in the observation group was significantly higher than 83.3%in the control group(P<0.05).After treatment,the observation group had a material life status score of(88.3±8.2)points,a social function score of(86.7±8.4)points,a psychological function score of(90.8±8.4)points,and a somatic function score of(89.2±8.4)points;the control group had a material life status score of(74.3±8.1)points,a social function score of(73.2±8.7)points,a psychological function score of(76.3±8.6)points,and a somatic function score of(74.6±8.3)points.The scores of psychological function,social function,somatic function,and material life status of the observation group were significantly higher than those of the control group(P<0.05).Conclusion The combination of modified Liyuan Decoction and quadruple therapy is of high value for patients with CG of spleen deficiency and stomach dryness type,and it can effectively improve the gastric mucosa injury of patients.
Chronic gastritisLiyuan DecoctionInjury of gastric mucosaSpleen deficiency and stomach dryness typeQuality of lifeQuadruple therapyInflammatory factors
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