Effect analysis of nasal feeding of Qingyi Jiedu Decoction plus external application of mirabilite combined with early enteral nutrition in the treatment of severe acute pancreatitis
Objective To analyze the effect of nasal feeding of Qingyi Jiedu Decoction plus external application of mirabilite combined with early enteral nutrition in the treatment of severe acute pancreatitis(SAP).Methods 100 patients with severe acute pancreatitis were divided into an observation group and a control group according to different treatment methods,with 50 cases in each group.The observation group was given nasal feeding of Qingyi Jiedu Decoction plus external application of mirabilite combined with early enteral nutrition,and the control group was given early enteral nutrition.The inflammatory factors,immune function,occurrence of adverse reactions and recovery time of gastrointestinal function were compared between the two groups.Results Before treatment,there was no significant difference in C-reactive protein(CRP),interleukin-1β(IL-1β)and interleukin-8(IL-8)between the two groups(P>0.05).After treatment,the observation group had CRP of(26.14±8.75)mg/L,IL-1β of(9.02±2.55)pg/ml and IL-8 of(19.24±3.21)ng/L,which were significantly lower than(36.84±10.69)mg/L,(12.63±2.89)pg/ml and(30.52±3.57)ng/L in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in CD3+,CD4+and CD8+between the two groups(P>0.05).After treatment,the observation group had CD3+of(46.25±5.51)%,CD4+of(44.21±4.15)%and CD8+of(21.25±3.11)%,which were significantly better than(44.25±4.12),(42.12±3.59)and(23.25±2.15)%in the control group.The difference was statistically significant(P<0.05).The incidence of adverse reactions of 2.00%in the observation group was lower than 14.00%in the control group,and the difference was statistically significant(P<0.05).In the observation group,the recovery time of exhaust was(2.41±1.25)d,the recovery time of bowel movements was(2.51±0.84)d,the recovery time of bowel sound was(2.41±0.45)d,and the relief time of abdominal discomfort was(4.15±0.75)d,which were significantly shorter than(4.52±1.69),(3.59±0.88),(3.59±0.74),and(7.04±1.22)d in the control group,and the difference was statistically significant(P<0.05).Conclusion Nasal feeding of Qingyi Jiedu Decoction plus external application of mirabilite combined with early enteral nutrition has a remarkable effect on the treatment of severe acute pancreatitis,and the recovery is faster.This treatment plan has certain promotion and application value.
Nasal feeding of Qingyi Jiedu DecoctionExternal application of mirabiliteEarly enteral nutritionSevere acute pancreatitis
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